Alcohol, drinking pattern and all-cause, cardiovascular and alcohol-related mortality in Eastern Europe
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
G0100222
Medical Research Council - United Kingdom
G0701830
Medical Research Council - United Kingdom
G0902037
Medical Research Council - United Kingdom
R01 AG023522
NIA NIH HHS - United States
WT081081
Wellcome Trust - United Kingdom
R01 AG23522
NIA NIH HHS - United States
G0601647
Medical Research Council - United Kingdom
G1000616
Medical Research Council - United Kingdom
RG/07/008/23674
British Heart Foundation - United Kingdom
G19/35
Medical Research Council - United Kingdom
G8802774
Medical Research Council - United Kingdom
PubMed
26467937
PubMed Central
PMC4756032
DOI
10.1007/s10654-015-0092-8
PII: 10.1007/s10654-015-0092-8
Knihovny.cz E-zdroje
- Klíčová slova
- Alcohol, Cardiovascular diseases, Eastern Europe, Mortality,
- MeSH
- alkoholismus komplikace mortalita MeSH
- časové faktory MeSH
- dospělí MeSH
- hodnocení rizik MeSH
- kardiovaskulární nemoci etiologie mortalita MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nárazové pití alkoholu komplikace mortalita MeSH
- otrava alkoholem komplikace mortalita MeSH
- pití alkoholu škodlivé účinky mortalita MeSH
- příčina smrti * MeSH
- proporcionální rizikové modely MeSH
- rizikové faktory MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Geografické názvy
- východní Evropa epidemiologie MeSH
Alcohol has been implicated in the high mortality in Central and Eastern Europe but the magnitude of its effect, and whether it is due to regular high intake or episodic binge drinking remain unclear. The aim of this paper was to estimate the contribution of alcohol to mortality in four Central and Eastern European countries. We used data from the Health, Alcohol and Psychosocial factors in Eastern Europe is a prospective multi-centre cohort study in Novosibirsk (Russia), Krakow (Poland), Kaunas (Lithuania) and six Czech towns. Random population samples of 34,304 men and women aged 45-69 years in 2002-2005 were followed up for a median 7 years. Drinking volume, frequency and pattern were estimated from the graduated frequency questionnaire. Deaths were ascertained using mortality registers. In 230,246 person-years of follow-up, 2895 participants died from all causes, 1222 from cardiovascular diseases (CVD), 672 from coronary heart disease (CHD) and 489 from pre-defined alcohol-related causes (ARD). In fully-adjusted models, abstainers had 30-50% increased mortality risk compared to light-to-moderate drinkers. Adjusted hazard ratios (HR) in men drinking on average ≥60 g of ethanol/day (3% of men) were 1.23 (95% CI 0.95-1.59) for all-cause, 1.38 (0.95-2.02) for CVD, 1.64 (1.02-2.64) for CHD and 2.03 (1.28-3.23) for ARD mortality. Corresponding HRs in women drinking on average ≥20 g/day (2% of women) were 1.92 (1.25-2.93), 1.74 (0.76-3.99), 1.39 (0.34-5.76) and 3.00 (1.26-7.10). Binge drinking increased ARD mortality in men only. Mortality was associated with high average alcohol intake but not binge drinking, except for ARD in men.
Collegium Medicum Jagiellonian University Kraków Poland
Institute of Cardiology Lithuanian University of Health Sciences Kaunas Lithuania
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