Whisper mutations: cryptic messages within the genetic code
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
26657150
DOI
10.1038/onc.2015.454
PII: onc2015454
Knihovny.cz E-zdroje
- MeSH
- genetický kód genetika MeSH
- kodon genetika MeSH
- lidé MeSH
- messenger RNA chemie genetika MeSH
- modely genetické MeSH
- mutace * MeSH
- otevřené čtecí rámce genetika MeSH
- proteiny chemie genetika metabolismus MeSH
- proteosyntéza genetika MeSH
- sbalování proteinů MeSH
- sbalování RNA MeSH
- stabilita RNA genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- kodon MeSH
- messenger RNA MeSH
- proteiny MeSH
Recent years have seen a great expansion in our understandings of how silent mutations can drive a disease and that mRNAs are not only mere messengers between the genome and the encoded proteins but also encompass regulatory activities. This review focuses on how silent mutations within open reading frames can affect the functional properties of the encoded protein. We describe how mRNAs exert control of cell biological processes governed by the encoded proteins via translation kinetics, protein folding, mRNA stability, spatio-temporal protein expression and by direct interactions with cellular factors. These examples illustrate how additional levels of information lie within the coding sequences and that the degenerative genetic code is not redundant and have co-evolved with the encoded proteins. Hence, so called synonymous mutations are not always silent but 'whisper'.
Instituto de Física Universidad Autónoma de San Luis Potosí San Luis Potosí México
RECAMO Masaryk Memorial Cancer Institute Zluty kopec 7 Brno Czech Republic
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PLoS One. 2008 May 14;3(5):e2174 PubMed
F1000 Biol Rep. 2012;4:16 PubMed
FASEB J. 2013 Nov;27(11):4630-45 PubMed
Mol Cell. 2010 Apr 9;38(1):78-88 PubMed
Cell. 2014 Mar 13;156(6):1324-35 PubMed
Biol Cell. 2007 Sep;99(9):475-87 PubMed
Cell. 2002 Nov 27;111(5):747-56 PubMed
Science. 2013 Dec 13;342(6164):1367-72 PubMed
Science. 2015 Apr 24;348(6233):444-8 PubMed
Mol Cell Biol. 2002 Jun;22(12):3959-69 PubMed
Hum Mutat. 2004 Nov;24(5):370-80 PubMed
Hum Mol Genet. 2003 Feb 1;12(3):205-16 PubMed
Nat Commun. 2014 Oct 08;5:5067 PubMed
Nat Rev Genet. 2011 Aug 31;12(10):683-91 PubMed
Nature. 1999 Jan 21;397(6716):271-4 PubMed
Pharmacogenomics. 2007 Aug;8(8):1075-80 PubMed
Oncogene. 2000 Mar 9;19(11):1473-6 PubMed
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11429-34 PubMed
Protein Sci. 1996 Aug;5(8):1594-612 PubMed
RNA. 2008 Nov;14(11):2333-47 PubMed
Mol Cell. 2000 Apr;5(4):607-16 PubMed
Genome Biol. 2007;8(11):R239 PubMed
Mutat Res. 2006 Aug 30;600(1-2):102-12 PubMed
Nat Genet. 2001 Sep;29(1):92-5 PubMed
Nature. 1997 May 15;387(6630):299-303 PubMed
Cell. 2015 Jun 18;161(7):1606-18 PubMed
Biochem Biophys Res Commun. 2002 Apr 26;293(1):537-41 PubMed
Nat Struct Mol Biol. 2014 Dec;21(12):1100-5 PubMed
Cell. 2014 Sep 11;158(6):1281-92 PubMed
Nat Cell Biol. 2008 Sep;10 (9):1098-105 PubMed
Nucleic Acids Res. 2010 Oct;38(19):6719-28 PubMed
Chem Biol. 2002 Sep;9(9):1043 PubMed
Nature. 1997 May 15;387(6630):296-9 PubMed
Cancer Lett. 2004 Jun 25;209(2):245-50 PubMed
Microb Cell Fact. 2009 Jul 24;8:41 PubMed
Mol Cell Biol. 2005 Jun;25(11):4752-66 PubMed
Int J Mol Med. 2014 Apr;33(4):747-62 PubMed
Nat Struct Mol Biol. 2009 Mar;16(3):274-80 PubMed
Curr Biol. 1999 Mar 25;9(6):333-6 PubMed
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15908-13 PubMed
Annu Rev Biophys. 2008;37:117-33 PubMed
Cancer Res. 2014 Jan 15;74(2):598-608 PubMed
Cancer Cell. 2012 Jan 17;21(1):25-35 PubMed
Mol Cell. 2014 May 8;54(3):500-11 PubMed
Genes Dev. 2010 Sep 1;24(17):1914-26 PubMed
Mol Cell. 2011 Sep 16;43(6):867-79 PubMed
RNA. 2009 Jan;15(1):104-15 PubMed
Science. 2007 Jan 26;315(5811):525-8 PubMed
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5273-8 PubMed
Cell. 2003 May 30;113(5):577-86 PubMed
Proc Natl Acad Sci U S A. 2005 May 3;102(18):6368-72 PubMed
Cell. 2015 Mar 12;160(6):1111-24 PubMed
Cold Spring Harb Perspect Biol. 2012 Feb 01;4(2):null PubMed
J Biol Chem. 2010 Sep 10;285(37):28741-8 PubMed
Bioinformatics. 2013 Jun 15;29(12):1488-91 PubMed
EMBO Rep. 2008 Aug;9(8):781-7 PubMed
Mutat Res. 2015 May;775:19-25 PubMed
J Am Chem Soc. 2014 Dec 31;136(52):17892-8 PubMed
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13481-6 PubMed
Mol Cell. 1997 Dec;1(1):3-11 PubMed
PLoS One. 2011;6(6):e21035 PubMed
Mol Cell. 2006 Aug 4;23(3):401-12 PubMed
Curr Protein Pept Sci. 2012 Jun;13(4):284-93 PubMed
Biochim Biophys Acta. 2007 Jan;1769(1):49-60 PubMed
Genes Cancer. 2010 Oct;1(10):1074-82 PubMed
Mol Cell. 2007 Jun 22;26(6):795-809 PubMed
Science. 2012 Oct 19;338(6105):397-400 PubMed
Biotechnol J. 2011 Jun;6(6):660-7 PubMed
Hum Mutat. 2007 Jun;28(6):622-9 PubMed
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