The role of steroid hormones in the development of intrahepatic cholestasis of pregnancy
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
26680481
DOI
10.33549/physiolres.933117
PII: 933117
Knihovny.cz E-zdroje
- MeSH
- intrahepatální cholestáza krev etiologie genetika MeSH
- komplikace těhotenství krev etiologie genetika MeSH
- lidé MeSH
- pohlavní steroidní hormony fyziologie MeSH
- těhotenství MeSH
- žlučové kyseliny a soli krev genetika MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- pohlavní steroidní hormony MeSH
- žlučové kyseliny a soli MeSH
Intrahepatic cholestasis of pregnancy (ICP) is a disorder of liver function, commonly occurring in the third trimester but sometimes also as soon as the end of the second trimester of pregnancy. Symptoms of this disorder include pruritus, plus abnormal values of bile acids and hepatic transaminases. After birth, symptoms disappear and liver function returns to normal. Though ICP is relatively non-complicated and often symptomatically mild from the point-of-view of the mother, it presents a serious risk to the fetus, making this disease the subject of great interest. The etiology and pathogenesis of ICP is multifactorial and as yet not fully elucidated. Hormonal factors likely play a significant role, along with genetic as well as exogenous factors. Here we summarize the knowledge of changes in steroid hormones and their role in the development of intrahepatic cholestasis of pregnancy. In addition, we consider the role of exogenous factors as possible triggers of steroid hormone changes, the relationship between metabolic steroids and bile acids, as well as the combination of these factors in the development of ICP in predisposed pregnant women.
Citace poskytuje Crossref.org
Steroid Metabolome Analysis in Dichorionic Diamniotic Twin Pregnancy