Dynamic changes of B-cell compartments in kidney transplantation: lack of transitional B cells is associated with allograft rejection
Language English Country Switzerland Media print-electronic
Document type Journal Article
PubMed
26839984
DOI
10.1111/tri.12751
Knihovny.cz E-resources
- Keywords
- B cells, kidney transplantation, rejection, transitional B cells,
- MeSH
- Allografts MeSH
- CD24 Antigen metabolism MeSH
- Tumor Necrosis Factor Receptor Superfamily, Member 7 metabolism MeSH
- ADP-ribosyl Cyclase 1 metabolism MeSH
- Time Factors MeSH
- Child MeSH
- Adult MeSH
- Immunologic Memory immunology MeSH
- Immunosuppression Therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Plasma Cells immunology MeSH
- B-Lymphocyte Subsets immunology MeSH
- Child, Preschool MeSH
- Precursor Cells, B-Lymphoid immunology MeSH
- Transplant Recipients MeSH
- Prospective Studies MeSH
- Graft Rejection immunology MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Kidney Transplantation * MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- CD24 Antigen MeSH
- Tumor Necrosis Factor Receptor Superfamily, Member 7 MeSH
- ADP-ribosyl Cyclase 1 MeSH
B cells play an important role in the immune responses which affect the outcomes of kidney allografts. Dynamic changes of B-cell compartments in clinical kidney transplantation are still poorly understood. B-cell subsets were prospectively monitored using flow cytometry for 1 year in 98 kidney transplant recipients. Data were correlated with immunosuppression and clinical outcomes. An increase in the total population of B lymphocytes was observed during the first week after transplantation. The level of IgM(high) CD38(high) CD24(high) transitional B cells reduced significantly up until the third month, with partial repopulation in the first year. Lower numbers of transitional B cells in the third month were associated with higher risk of graft rejection. IgM(+) IgD(+) CD27(-) naive B cells did not change within follow-up. IgM(+) CD27(+) nonswitched memory B cells and IgM(-) CD27(+) switched memory B cells increased on post-operative day 7. IgM(-) CD38(high) CD27(high) plasmablasts showed similar kinetics during the first post-transplant year, similar to transitional B cells. In conclusion, sensitized kidney transplant recipients as well as those with either acute or chronic rejection within the first post-transplant year exhibited lower levels of transitional B cells. Therefore, these data further support the hypothesis that transitional B cells have a protective role in kidney transplantation.
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