Dynamic changes of B-cell compartments in kidney transplantation: lack of transitional B cells is associated with allograft rejection
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
26839984
DOI
10.1111/tri.12751
Knihovny.cz E-zdroje
- Klíčová slova
- B cells, kidney transplantation, rejection, transitional B cells,
- MeSH
- alografty MeSH
- antigen CD24 metabolismus MeSH
- antigeny CD27 metabolismus MeSH
- antigeny CD38 metabolismus MeSH
- časové faktory MeSH
- dítě MeSH
- dospělí MeSH
- imunologická paměť imunologie MeSH
- imunosupresivní léčba MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- plazmatické buňky imunologie MeSH
- podskupiny B-lymfocytů imunologie MeSH
- předškolní dítě MeSH
- prekurzorové B-lymfoidní buňky imunologie MeSH
- příjemce transplantátu MeSH
- prospektivní studie MeSH
- rejekce štěpu imunologie MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- transplantace ledvin * MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigen CD24 MeSH
- antigeny CD27 MeSH
- antigeny CD38 MeSH
B cells play an important role in the immune responses which affect the outcomes of kidney allografts. Dynamic changes of B-cell compartments in clinical kidney transplantation are still poorly understood. B-cell subsets were prospectively monitored using flow cytometry for 1 year in 98 kidney transplant recipients. Data were correlated with immunosuppression and clinical outcomes. An increase in the total population of B lymphocytes was observed during the first week after transplantation. The level of IgM(high) CD38(high) CD24(high) transitional B cells reduced significantly up until the third month, with partial repopulation in the first year. Lower numbers of transitional B cells in the third month were associated with higher risk of graft rejection. IgM(+) IgD(+) CD27(-) naive B cells did not change within follow-up. IgM(+) CD27(+) nonswitched memory B cells and IgM(-) CD27(+) switched memory B cells increased on post-operative day 7. IgM(-) CD38(high) CD27(high) plasmablasts showed similar kinetics during the first post-transplant year, similar to transitional B cells. In conclusion, sensitized kidney transplant recipients as well as those with either acute or chronic rejection within the first post-transplant year exhibited lower levels of transitional B cells. Therefore, these data further support the hypothesis that transitional B cells have a protective role in kidney transplantation.
Citace poskytuje Crossref.org
