Gut Microbiome of Coexisting BaAka Pygmies and Bantu Reflects Gradients of Traditional Subsistence Patterns

. 2016 Mar 08 ; 14 (9) : 2142-2153. [epub] 20160225

Jazyk angličtina Země Spojené státy americké Médium print-electronic

Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid26923597
Odkazy

PubMed 26923597
DOI 10.1016/j.celrep.2016.02.013
PII: S2211-1247(16)30099-7
Knihovny.cz E-zdroje

To understand how the gut microbiome is impacted by human adaptation to varying environments, we explored gut bacterial communities in the BaAka rainforest hunter-gatherers and their agriculturalist Bantu neighbors in the Central African Republic. Although the microbiome of both groups is compositionally similar, hunter-gatherers harbor increased abundance of Prevotellaceae, Treponema, and Clostridiaceae, while the Bantu gut microbiome is dominated by Firmicutes. Comparisons with US Americans reveal microbiome differences between Africans and westerners but show western-like features in the Bantu, including an increased abundance of predictive carbohydrate and xenobiotic metabolic pathways. In contrast, the hunter-gatherer gut shows increased abundance of predicted virulence, amino acid, and vitamin metabolism functions, as well as dominance of lipid and amino-acid-derived metabolites, as determined through metabolomics. Our results demonstrate gradients of traditional subsistence patterns in two neighboring African groups and highlight the adaptability of the microbiome in response to host ecology.

Department of Animal and Range Sciences Montana State University Bozeman MT 59717 USA

Department of Anthropology Northwestern University Evanston IL 60208 USA

Department of Anthropology Purdue University West Lafayette IN 47907 USA

Department of Anthropology University of North Carolina Wilmington NC 28403 USA

Department of Food Science University of Arkansas Fayetteville AK 72704 USA

Department of Genetics Cell Biology and Development University of Minnesota Twin Cities MN 55108 USA; Department of Ecology Evolution and Behavior University of Minnesota Twin Cities MN 55108 USA

Dzanga Sangha Protected Areas World Wildlife Fund Bayanga Central African Republic

Faculty of Veterinary Medicine Department of Pathology and Parasitology University of Veterinary and Pharmaceutical Sciences Brno 612 42 Czech Republic

Institute for Genomic Biology University of Illinois at Urbana Champaign Urbana IL 61801 USA

Institute for Genomic Biology University of Illinois at Urbana Champaign Urbana IL 61801 USA; Department of Animal Sciences University of Illinois at Urbana Champaign Urbana IL 61801 USA

Institute for Genomic Biology University of Illinois at Urbana Champaign Urbana IL 61801 USA; Department of Anthropology University of Illinois at Urbana Champaign Urbana IL 61801 USA

Institute for Genomic Biology University of Illinois at Urbana Champaign Urbana IL 61801 USA; Department of Anthropology University of Illinois at Urbana Champaign Urbana IL 61801 USA; Department of Anthropology University of Colorado Boulder CO 80309 USA

Institute for Genomic Biology University of Illinois at Urbana Champaign Urbana IL 61801 USA; Department of Microbiology University of Illinois at Urbana Champaign Urbana IL 61801 USA

Institute of Parasitology Biology Centre of the Academy of Sciences of the Czech Republic České Budějovice 370 05 Czech Republic; Faculty of Veterinary Medicine Department of Pathology and Parasitology University of Veterinary and Pharmaceutical Sciences Brno 612 42 Czech Republic; CEITEC Central European Institute for Technology University of Veterinary and Pharmaceutical Sciences Brno 612 42 Czech Republic

Institute of Vertebrate Biology Academy of Sciences of the Czech Republic Brno 603 65 Czech Republic; Institute of Parasitology Biology Centre of the Academy of Sciences of the Czech Republic České Budějovice 370 05 Czech Republic; Liberec Zoo Liberec 460 01 Czech Republic

The J Craig Venter Institute La Jolla CA 92037 USA

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