Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
26961769
DOI
10.1039/c6nr00791k
Knihovny.cz E-resources
- MeSH
- Fluorescent Dyes chemistry pharmacokinetics MeSH
- Microscopy, Fluorescence methods MeSH
- Cells, Cultured MeSH
- Boronic Acids chemistry MeSH
- Drug Delivery Systems methods MeSH
- Humans MeSH
- Nanoparticles chemistry MeSH
- Drug Carriers chemistry pharmacokinetics MeSH
- Oxazines chemistry pharmacokinetics MeSH
- Polymers chemistry MeSH
- Reactive Oxygen Species pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Fluorescent Dyes MeSH
- Boronic Acids MeSH
- nile red MeSH Browser
- Drug Carriers MeSH
- Oxazines MeSH
- Polymers MeSH
- Reactive Oxygen Species MeSH
A new drug-delivery system of polymer nanoparticles (NPs) bearing pinacol-type boronic ester and alkyne moieties displaying triggered self-immolative polymer degradation in the presence of reactive oxygen species (ROS) with the capability of cellular imaging is presented. The NPs specifically release their drug cargo under concentrations of ROS that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts.
References provided by Crossref.org
Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy
