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Effect of Antibiotic Treatment on the Gastrointestinal Microbiome of Free-Ranging Western Lowland Gorillas (Gorilla g. gorilla)

Vlčková, Klára
Author Vlčková, Klára Department of Pathology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, Brno, 61242, Czech Republic. klari.vlckova@gmail.com
Gomez, Andres
Author Gomez, Andres J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA, 92037, USA Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL, 61801, USA
Petrželková, Klára J
Author Petrželková, Klára J Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Květná 8, Brno, 60365, Czech Republic Liberec Zoo, Masarykova 1347/31, Liberec, 46001, Czech Republic Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská 31, České Budějovice, 37005, Czech Republic
Whittier, Christopher A
Author Whittier, Christopher A Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Road, North Grafton, MA, 01536, USA Department of Wildlife Health Sciences, Smithsonian Conservation Biology Institute, National Zoological Park, 3001 Connecticut Avenue Northwest, Washington, DC, 20008, USA
Todd, Angelique F
Author Todd, Angelique F WWF, Dzanga Sangha Protected Areas, BP 1053, Bangui, Central African Republic
Yeoman, Carl J
Author Yeoman, Carl J Department of Animal and Range Sciences, Montana State University, P.O. Box 172900, Bozeman, MT, 59717-2900, USA
Nelson, Karen E
Author Nelson, Karen E J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD, 20850, USA J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA, 92037, USA
Wilson, Brenda A
Author Wilson, Brenda A Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL, 61801, USA Department of Microbiology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, Urbana, IL, 61801, USA
Stumpf, Rebecca M
Author Stumpf, Rebecca M Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL, 61801, USA Department of Anthropology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana, IL, 61801, USA
Modrý, David
Author Modrý, David Department of Pathology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, Brno, 61242, Czech Republic Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská 31, České Budějovice, 37005, Czech Republic CEITEC VFU, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, Brno, 61242, Czech Republic
White, Bryan A
Author White, Bryan A Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL, 61801, USA
Leigh, Steven R
Author Leigh, Steven R Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL, 61801, USA Department of Anthropology, University of Colorado at Boulder, 1350 Pleasant Street, Boulder, CO, 80309-0233, USA

Microbial ecology. 2016 Nov ; 72 (4) : 943-954. [epub] 20160316

Microb Ecol
ISSN 1432-184X | 0095-3628
Source

Language English Country United States Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.

Persistent link https://www.medvik.cz/link/pmid26984253

PubMed 26984253
DOI 10.1007/s00248-016-0745-5
PII: 10.1007/s00248-016-0745-5
Knihovny.cz E-resources

Keywords
Antibiotics, Bacteria, Gastrointestinal microbiome, Gorilla, Illumina MiSeq, Medical treatment,
MeSH
Anti-Bacterial Agents pharmacology MeSH
Bacteroidetes growth & development MeSH
Cephalosporins pharmacology MeSH
Feces microbiology MeSH
Firmicutes growth & development MeSH
Gorilla gorilla microbiology MeSH
Ape Diseases drug therapy MeSH
RNA, Ribosomal, 16S genetics MeSH
Ruminococcus growth & development MeSH
Gastrointestinal Microbiome drug effects MeSH
Animals MeSH
Check Tag
Animals MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Research Support, U.S. Gov't, Non-P.H.S. MeSH
Geographicals
Central African Republic MeSH
Names of Substances
Anti-Bacterial Agents MeSH
Cephalosporins MeSH
RNA, Ribosomal, 16S MeSH

The mammalian gastrointestinal (GI) microbiome, which plays indispensable roles in host nutrition and health, is affected by numerous intrinsic and extrinsic factors. Among them, antibiotic (ATB) treatment is reported to have a significant effect on GI microbiome composition in humans and other animals. However, the impact of ATBs on the GI microbiome of free-ranging or even captive great apes remains poorly characterized. Here, we investigated the effect of cephalosporin treatment (delivered by intramuscular dart injection during a serious respiratory outbreak) on the GI microbiome of a wild habituated group of western lowland gorillas (Gorilla gorilla gorilla) in the Dzanga Sangha Protected Areas, Central African Republic. We examined 36 fecal samples from eight individuals, including samples before and after ATB treatment, and characterized the GI microbiome composition using Illumina-MiSeq sequencing of the bacterial 16S rRNA gene. The GI microbial profiles of samples from the same individuals before and after ATB administration indicate that the ATB treatment impacts GI microbiome stability and the relative abundance of particular bacterial taxa within the colonic ecosystem of wild gorillas. We observed a statistically significant increase in Firmicutes and a decrease in Bacteroidetes levels after ATB treatment. We found disruption of the fibrolytic community linked with a decrease of Ruminoccocus levels as a result of ATB treatment. Nevertheless, the nature of the changes observed after ATB treatment differs among gorillas and thus is dependent on the individual host. This study has important implications for ecology, management, and conservation of wild primates.

Carl R Woese Institute for Genomic Biology University of Illinois at Urbana Champaign 1206 West Gregory Drive Urbana IL 61801 USA

CEITEC VFU University of Veterinary and Pharmaceutical Sciences Brno Palackého tř 1 3 Brno 61242 Czech Republic

Cummings School of Veterinary Medicine at Tufts University 200 Westboro Road North Grafton MA 01536 USA

Department of Animal and Range Sciences Montana State University P O Box 172900 Bozeman MT 59717 2900 USA

Department of Anthropology University of Colorado at Boulder 1350 Pleasant Street Boulder CO 80309 0233 USA

Department of Anthropology University of Illinois at Urbana Champaign 607 South Mathews Avenue Urbana IL 61801 USA

Department of Microbiology University of Illinois at Urbana Champaign 601 South Goodwin Avenue Urbana IL 61801 USA

Department of Pathology and Parasitology Faculty of Veterinary Medicine University of Veterinary and Pharmaceutical Sciences Brno Palackého tř 1 3 Brno 61242 Czech Republic

Department of Wildlife Health Sciences Smithsonian Conservation Biology Institute National Zoological Park 3001 Connecticut Avenue Northwest Washington DC 20008 USA

Institute of Parasitology Biology Centre of the Academy of Sciences of the Czech Republic Branišovská 31 České Budějovice 37005 Czech Republic

Institute of Vertebrate Biology Academy of Sciences of the Czech Republic Květná 8 Brno 60365 Czech Republic

J Craig Venter Institute 4120 Capricorn Lane La Jolla CA 92037 USA