Polysaccharide-based nanocomplexes for co-encapsulation and controlled release of 5-Fluorouracil and Temozolomide
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
27154260
DOI
10.1016/j.ejps.2016.05.001
PII: S0928-0987(16)30155-5
Knihovny.cz E-resources
- Keywords
- 5-Fluorouracil (PubChem CID: 3385), Alginic acid, Alginic acid (PubChem CID: 44630049), Chitosan, Chitosan (PubChem CID: 21896651), Drug delivery, Polyelectrolytes, Polygalacturonic acid, Polygalacturonic acid (PubChem CID: 439215), Temozolomide (PubChem CID: 11830328),
- MeSH
- Alginates chemistry MeSH
- Antineoplastic Agents, Alkylating chemistry MeSH
- Chitosan chemistry MeSH
- Dacarbazine analogs & derivatives chemistry MeSH
- Drug Combinations MeSH
- Fluorouracil chemistry MeSH
- Glucuronic Acid chemistry MeSH
- Hexuronic Acids chemistry MeSH
- Delayed-Action Preparations chemistry MeSH
- Nanoparticles chemistry MeSH
- Drug Carriers chemistry MeSH
- Pectins chemistry MeSH
- Prodrugs chemistry MeSH
- Drug Compounding MeSH
- Antimetabolites, Antineoplastic chemistry MeSH
- Drug Stability MeSH
- Temozolomide MeSH
- Drug Liberation MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Alginates MeSH
- Antineoplastic Agents, Alkylating MeSH
- Chitosan MeSH
- Dacarbazine MeSH
- Drug Combinations MeSH
- Fluorouracil MeSH
- Glucuronic Acid MeSH
- Hexuronic Acids MeSH
- Delayed-Action Preparations MeSH
- Drug Carriers MeSH
- Pectins MeSH
- polygalacturonic acid MeSH Browser
- Prodrugs MeSH
- Antimetabolites, Antineoplastic MeSH
- Temozolomide MeSH
Polysaccharide-based nanocomplexes, intended for simultaneous encapsulation and controlled release of 5-Fluorouracil (5-FU) and Temozolomide (TMZ) were developed via the complexation method using chitosan, alginic and polygalacturonic acid. Investigation focused on the influence of polysaccharides on the properties of the system and amelioration of the stability of the drugs, in particular TMZ. The dimensions of particles and their ζ-potential were found to range between 100 and 200nm and -25 to +40mV, respectively. Encapsulation efficiency varied from 16% to over 70%, depending on the given system. The influence of pH on the release and co-release of TMZ and 5-FU was evaluated under different pH conditions. The stability of the loaded drug, in particular TMZ, after release was evaluated and confirmed by LC-MS analysis. Results suggested that the amount of loaded drug(s) and the release rate is connected with the weight ratio of polysaccharides and the pH of the media. One-way ANOVA analysis on the obtained data revealed no interference between the drugs during the encapsulation and release process, and in particular no hydrolysis of TMZ occurred suggesting that CS-ALG and CS-PGA would represent interesting carriers for multi-drug controlled release and drugs protection.
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