Effect of Simvastatin, Coenzyme Q10, Resveratrol, Acetylcysteine and Acetylcarnitine on Mitochondrial Respiration
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
27187037
DOI
10.14712/fb2016062020053
PII: file/5803/fb2016a0007.pdf
Knihovny.cz E-zdroje
- MeSH
- acetylcystein farmakologie MeSH
- acylkarnitin farmakologie MeSH
- buněčné dýchání účinky léků MeSH
- mitochondrie účinky léků metabolismus MeSH
- mozek účinky léků MeSH
- neuroprotektivní látky farmakologie MeSH
- prasata MeSH
- respirační komplex IV metabolismus MeSH
- resveratrol MeSH
- simvastatin farmakologie MeSH
- spotřeba kyslíku účinky léků MeSH
- stilbeny farmakologie MeSH
- ubichinon analogy a deriváty farmakologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- acetylcystein MeSH
- acylkarnitin MeSH
- coenzyme Q10 MeSH Prohlížeč
- neuroprotektivní látky MeSH
- respirační komplex IV MeSH
- resveratrol MeSH
- simvastatin MeSH
- stilbeny MeSH
- ubichinon MeSH
Some therapeutic and/or adverse effects of drugs may be related to their effects on mitochondrial function. The effects of simvastatin, resveratrol, coenzyme Q10, acetylcysteine, and acetylcarnitine on Complex I-, Complex II-, or Complex IV-linked respiratory rate were determined in isolated brain mitochondria. The protective effects of these biologically active compounds on the calcium-induced decrease of the respiratory rate were also studied. We observed a significant inhibitory effect of simvastatin on mitochondrial respiration (IC50 = 24.0 μM for Complex I-linked respiration, IC50 = 31.3 μM for Complex II-linked respiration, and IC50 = 42.9 μM for Complex IV-linked respiration); the inhibitory effect of resveratrol was found at very high concentrations (IC50 = 162 μM for Complex I-linked respiration, IC50 = 564 μM for Complex II-linked respiration, and IC50 = 1454 μM for Complex IV-linked respiration). Concentrations required for effective simvastatin- or resveratrol-induced inhibition of mitochondrial respiration were found much higher than concentrations achieved under standard dosing of these drugs. Acetylcysteine and acetylcarnitine did not affect the oxygen consumption rate of mitochondria. Coenzyme Q10 induced an increase of Complex I-linked respiration. The increase of free calcium ions induced partial inhibition of the Complex I+II-linked mitochondrial respiration, and all tested drugs counteracted this inhibition. None of the tested drugs showed mitochondrial toxicity (characterized by respiratory rate inhibition) at drug concentrations achieved at therapeutic drug intake. Resveratrol, simvastatin, and acetylcarnitine had the greatest neuroprotective potential (characterized by protective effects against calcium-induced reduction of the respiratory rate).
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