Novel electrospun gelatin/oxycellulose nanofibers as a suitable platform for lung disease modeling
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
27287147
DOI
10.1016/j.msec.2016.05.059
PII: S0928-4931(16)30494-5
Knihovny.cz E-resources
- Keywords
- Antibacterial, Electrospinning, Gelatin, Nanofibers, Oxycellulose, Regenerative medicine,
- MeSH
- Adenocarcinoma drug therapy metabolism pathology MeSH
- Cellulose, Oxidized * chemistry pharmacology MeSH
- Escherichia coli growth & development MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Lung Neoplasms drug therapy metabolism pathology MeSH
- Nanofibers chemistry MeSH
- Gelatin * chemistry pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cellulose, Oxidized * MeSH
- Gelatin * MeSH
Novel hydrolytically stable gelatin nanofibers modified with sodium or calcium salt of oxycellulose were prepared by electrospinning method. The unique inhibitory effect of these nanofibers against Escherichia coli bacteria was examined by luminometric method. Biocompatibility of these gelatin/oxycellulose nanofibers with eukaryotic cells was tested using human lung adenocarcinoma cell line NCI-H441. Cells firmly adhered to nanofiber surface, as determined by scanning electron microscopy, and no signs of cell dying were detected by fluorescent live/dead assay. We propose that the newly developed gelatin/oxycellulose nanofibers could be used as promising scaffold for lung disease modeling and anti-cancer drug testing.
Department of Physical Electronics Masaryk University Czech Republic
Institute of Experimental Biology Masaryk University Czech Republic
Institute of Materials Chemistry Brno University of Technology Czech Republic
References provided by Crossref.org
Well-Blended PCL/PEO Electrospun Nanofibers with Functional Properties Enhanced by Plasma Processing
