UNLABELLED: The aim of our study was to investigate whether nocturnal blood pressure (BP) dip is associated with increased left ventricular mass index and hypertrophy in children with hypertension (HT). We retrospectively reviewed data from all children with confirmed ambulatory HT in our center and performed ambulatory blood pressure monitoring (ABPM) and echocardiography at the same time. Left ventricular hypertrophy (LVH) was defined as left ventricular mass index (LVMI) ≥95th centile. Non-dipping phenomenon was defined as nocturnal BP dip <10 %. A total of 114 ABPM studies were included, the median age of children was 15.3 years (3.8-18.9), 80 children had renoparenchymal HT without end-stage renal failure, 34 had primary HT, and 27 studies were done on untreated children and 87 on treated children. Non-dipping phenomenon was present in 63 (55 %) studies (non-dippers). The LVMI adjusted for age was not significantly different between non-dippers and dippers (0.87 ± 0.03 vs. 0.81 ± 0.02, p = 0.13). Left ventricular hypertrophy was not significantly higher in non-dippers than in dippers (20 vs. 9 %, p = 0.12). CONCLUSION: Hypertensive children without end-stage renal failure with non-dipping phenomenon do not have increased prevalence of LVH or higher LVMI adjusted for age than hypertensive children with preserved nocturnal BP dip. WHAT IS KNOWN: • Adult and pediatric hypertensive patients with end-stage renal failure have often nocturnal blood pressure non-dipping phenomenon. • Non-dipping phenomenon is in patients with end-stage renal failure associated with increased prevalence of left ventricular hypertrophy. What is New: • Pediatric hypertensive patients without end-stage renal failure with blood pressure non-dipping phenomenon do not have increased prevalence of left ventricular hypertrophy.

Department of Pediatrics 2nd Medical School University Hospital Motol Charles University Prague 5 Úvalu 84 15006 Prague Czech Republic

Kardiocentrum and Centre for Cardiovascular Research University Hospital Motol Prague Czech Republic

Zobrazit více v PubMed

Cent Eur J Public Health. 2004 Sep;12 (3):126-30 PubMed

Am J Kidney Dis. 2005 Apr;45(4 Suppl 3):S1-153 PubMed

Pediatr Transplant. 2006 May;10(3):316-22 PubMed

Blood Press Monit. 2000 Apr;5(2):59-63 PubMed

J Hum Hypertens. 2003 Apr;17 (4):245-51 PubMed

Am J Hypertens. 1998 Apr;11(4 Pt 1):410-7 PubMed

Pediatrics. 2004 Aug;114(2 Suppl 4th Report):555-76 PubMed

Eur J Pediatr. 2014 Nov;173(11):1511-8 PubMed

J Pediatr. 2006 Nov;149(5):671-5 PubMed

Pediatr Nephrol. 2013 Aug;28(8):1275-82 PubMed

J Endocrinol Invest. 2008 Apr;31(4):289-96 PubMed

Am J Cardiol. 1986 Feb 15;57(6):450-8 PubMed

J Hypertens. 2002 Oct;20(10):1995-2007 PubMed

Pediatrics. 2003 Jun;111(6 Pt 1):1416-21 PubMed

Circulation. 1978 Dec;58(6):1072-83 PubMed

Eur J Echocardiogr. 2010 Apr;11(3):271-7 PubMed

Hypertension. 2002 Apr;39(4):903-8 PubMed

J Hypertens. 2001 Sep;19(9):1539-45 PubMed

Pediatr Nephrol. 2011 Mar;26(3):449-57 PubMed

Nephrol Dial Transplant. 2003 Mar;18(3):563-9 PubMed

J Hypertens. 2002 Nov;20(11):2131-3 PubMed

N Engl J Med. 2002 Sep 12;347(11):797-805 PubMed

Clin J Am Soc Nephrol. 2011 Apr;6(4):870-6 PubMed

J Hypertens. 2002 Nov;20(11):2183-9 PubMed

Curr Opin Nephrol Hypertens. 2008 May;17(3):292-7 PubMed

J Hypertens. 2014 Dec;32(12):2315-31; discussion 2331 PubMed

Hypertension. 2011 Jan;57(1):3-10 PubMed

Hypertension. 2008 Sep;52(3):433-51 PubMed

Am J Cardiol. 1995 Oct 1;76(10 ):699-701 PubMed

J Hypertens. 2009 Sep;27(9):1719-42 PubMed

Pediatr Nephrol. 2010 Jul;25(7):1311-8 PubMed

Pediatr Nephrol. 2006 Jun;21(6):811-9 PubMed

Am J Hypertens. 2012 Mar;25(3):389-95 PubMed

J Am Soc Echocardiogr. 2009 Jun;22(6):709-14 PubMed

Isolated nocturnal hypertension is associated with increased left ventricular mass index in children