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Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

. 2016 Sep ; 32 (9) : 708-723. [epub] 20160622

Language English Country England, Great Britain Media print-electronic

Document type Journal Article, Review, Research Support, Non-U.S. Gov't

Links

PubMed 27344362
DOI 10.1016/j.pt.2016.05.015
PII: S1471-4922(16)30078-2
Knihovny.cz E-resources

Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind.

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