Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
27344362
DOI
10.1016/j.pt.2016.05.015
PII: S1471-4922(16)30078-2
Knihovny.cz E-zdroje
- Klíčová slova
- aspartic peptidases, cathepsin D, hemoglobinolysis, parasites, vectors,
- MeSH
- antiparazitární látky farmakologie terapeutické užití MeSH
- inhibitory enzymů farmakologie MeSH
- lékové transportní systémy * MeSH
- parazitární nemoci farmakoterapie enzymologie MeSH
- paraziti enzymologie MeSH
- proteasy metabolismus MeSH
- transport proteinů genetika MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- antiparazitární látky MeSH
- inhibitory enzymů MeSH
- proteasy MeSH
Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind.
Citace poskytuje Crossref.org
Plasmepsin-like Aspartyl Proteases in Babesia
Protease Inhibition-An Established Strategy to Combat Infectious Diseases
