The Impact of Blood Pressure and Visceral Adiposity on the Association of Serum Uric Acid With Albuminuria in Adults Without Full Metabolic Syndrome
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
27565787
DOI
10.1093/ajh/hpw098
PII: hpw098
Knihovny.cz E-zdroje
- Klíčová slova
- albumin/creatinine ratio, blood pressure, hypertension, mean arterial pressure, metabolic syndrome, uric acid, visceral adiposity index.,
- MeSH
- adipozita * MeSH
- albuminurie diagnóza epidemiologie patofyziologie moč MeSH
- biologické markery krev moč MeSH
- dospělí MeSH
- fenotyp MeSH
- hodnoty glomerulární filtrace MeSH
- hypertenze diagnóza epidemiologie patofyziologie MeSH
- hyperurikemie krev diagnóza epidemiologie MeSH
- kreatinin moč MeSH
- krevní tlak * MeSH
- kyselina močová krev MeSH
- ledviny patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lineární modely MeSH
- metabolický syndrom krev diagnóza epidemiologie patofyziologie MeSH
- nitrobřišní tuk patofyziologie MeSH
- obezita diagnóza epidemiologie patofyziologie MeSH
- prediktivní hodnota testů MeSH
- průřezové studie MeSH
- rizikové faktory MeSH
- rozdělení chí kvadrát MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- biologické markery MeSH
- kreatinin MeSH
- kyselina močová MeSH
BACKGROUND: The impact of metabolic phenotypes on the association of uricemia with urinary albumin/creatinine ratio (uACR) remains unresolved. We evaluated the association between serum uric acid and uACR in persons with 0, and 1-2 metabolic syndrome (MetS) components and determined the modification effects of visceral adiposity index (VAI), mean arterial pressure (MAP), and fasting glucose on this association. METHODS: Using data from a cross-sectional survey of a representative Czech population aged 25-64 years (n = 3612), we analyzed 1,832 persons without decreased glomerular filtration rate <60ml/min/1.73 m2, diabetes, and MetS. MetS components were defined using the joint statement of the leading societies. RESULTS: Of the 1,832 selected participants, 64.1% (n = 1174) presented with 1-2 MetS components (age 46.3±11.2; men 51.7%), whereas 35.9% (n = 658) were free of any component (age 39.4±10.0; men 34.2 %). In fully adjusted multiple linear regression models for uricemia, uACR was an independent factor for increase in uric acid levels only in persons with 1-2 MetS components (standardized beta (Sβ) 0.048; P = 0.024); however, not in those without any component (Sβ 0.030; P = 0.264). Uric acid levels increased by the interaction of uACR with VAI (Sβ 0.06; P = 0.012), and of uACR with MAP (Sβ 0.05; P = 0.009). Finally, the association of uACR with uricemia was confined to persons whose VAI together with MAP were ≥the median of 1.35 and 98mm Hg, respectively (Sβ 0.190; P < 0.001). CONCLUSIONS: We demonstrated a strong modification effect of VAI and MAP on the association between uACR and uricemia, which suggests obesity-related hypertension as the underlying mechanism.
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