Prognostic Significance of TMPRSS2-ERG Fusion Gene in Prostate Cancer
Language English Country Greece Media print
Document type Journal Article
PubMed
27630329
DOI
10.21873/anticanres.11037
PII: 36/9/4787
Knihovny.cz E-resources
- Keywords
- PCA3, PSA, Prostate cancer, TMPRSS2-ERG, microRNA, prognosis,
- MeSH
- Antigens, Neoplasm biosynthesis genetics MeSH
- Adult MeSH
- Oncogene Proteins, Fusion genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasm Recurrence, Local blood genetics pathology MeSH
- MicroRNAs biosynthesis genetics MeSH
- Biomarkers, Tumor biosynthesis blood genetics MeSH
- Prostatic Neoplasms blood genetics pathology surgery MeSH
- Predictive Value of Tests MeSH
- Prognosis MeSH
- Proportional Hazards Models MeSH
- Prostate pathology MeSH
- Prostatectomy MeSH
- Prostate-Specific Antigen blood MeSH
- Gene Expression Regulation, Neoplastic MeSH
- Risk Factors MeSH
- Aged MeSH
- Paraffin Embedding MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antigens, Neoplasm MeSH
- Oncogene Proteins, Fusion MeSH
- MicroRNAs MeSH
- MIRN221 microRNA, human MeSH Browser
- MIRN23a microRNA, human MeSH Browser
- MIRN26A microRNA, human MeSH Browser
- Biomarkers, Tumor MeSH
- prostate cancer antigen 3, human MeSH Browser
- Prostate-Specific Antigen MeSH
- TMPRSS2-ERG fusion protein, human MeSH Browser
BACKGROUND/AIM: Current research of prostate cancer (PCa) offers a promising way of identifying patients with adverse prognosis who do benefit from radical treatment that can affect quality of life as resections are associated with numerous side-effects. The aim of our study was to evaluate the relationship of TMPRSS2-ERG fusion gene status, tumor tissue prostate-specific antigen (PSA), prostate cancer antigen 3 (PCA3), miR-23b, miR-26a and miR-221 expression levels in combination with preoperative serum PSA level to the risk of PCa recurrence after radical prostatectomy. PATIENTS AND METHODS: The study group consisted of 108 patients who underwent radical prostatectomy. PSA was measured in peripheral blood collected preoperativelly. The expression of TMPRSS2-ERG transcript and the expression of miR-23b, miR-26a and miR-221 in formalin-fixed, paraffin-embedded (FFPE) tumor tissues was analyzed by reverse transcription (RT) real-time polymerase chain reaction (PCR). RESULTS: Significantly shorter time to recurrence was observed in patients with high expression of TMPRSS2-ERG (p=0.0020). High levels of preoperative PSA (>10.0 ng/ml) proved to be marker of shorter time to recurrence (p=0.0153). The most promising marker of the risk of recurrence after radical prostatectomy was a combination of high level of preoperative serum PSA and high expression of TMPRSS2-ERG fusion transcript in tumor tissue (p=0.0001). CONCLUSION: A combination of high preoperative serum PSA and high expression of TMPRSS2-ERG could be promising in distinguishing those tumors that are aggressive and life-threatening.
Department of Biology Faculty of Medicine in Pilsen Charles University Prague Pilsen Czech Republic
Department of Urology Faculty of Medicine in Pilsen Charles University Prague Pilsen Czech Republic
Institute of Microbiology v v i Academy of Sciences of the Czech Republic Prague Czech Republic
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