Lipopeptides as therapeutics: applications and in vivo quantitative analysis
Language English Country Great Britain, England Media print
Document type Journal Article, Review
PubMed
27960546
DOI
10.4155/bio-2016-0206
Knihovny.cz E-resources
- Keywords
- LC–MS, immunomethods, lipopeptides,
- MeSH
- Solid Phase Extraction MeSH
- Ghrelin analysis isolation & purification MeSH
- Mass Spectrometry * MeSH
- Immunoassay * MeSH
- Humans MeSH
- Lipopeptides analysis isolation & purification MeSH
- Protein Binding MeSH
- Chromatography, High Pressure Liquid MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Ghrelin MeSH
- Lipopeptides MeSH
A number of novel lipopeptides have been studied for their possible therapeutic potential. These studies should be supported by the appropriate analytical tools not only for novel potential drugs but also for their metabolites, precursors and side products. Lipopeptides have specific physicochemical properties that make them successful in medical applications. However, there are some difficulties with their qualitative and quantitative analyses in biological samples. Therefore, reliable, sensitive and robust analytical methods are in high demand. The main interest of our review is to describe a selection of specific and important properties of lipopeptides, and the analytical methods currently utilized for their characterization and determination in biological samples. A comparison of the pros and cons of immunomethods versus LC-MS methods is discussed in detail.
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