Voltage-gated calcium channels (VGCCs) are transmembrane proteins that translate electrical activities into intracellular calcium elevations and downstream signaling pathways. They serve essential physiological functions including communication between nerve cells, muscle contraction, cardiac activity, and release of hormones and neurotransmitters. Asparagine-linked glycosylation has emerged as an essential post-translational modification to control the number of channels embedded in the plasma membrane but also their functional gating properties. This review provides a comprehensive overview about the current state of knowledge on the role of glycosylation in the expression and functioning of VGCCs, and discusses how variations in the glycosylation of the channel proteins can contribute to pathological conditions.

Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences Prague Czech Republic

Citace poskytuje Crossref.org

The T-type calcium channelosome

Transcriptomic analysis of glycan-processing genes in the dorsal root ganglia of diabetic mice and functional characterization on Cav3.2 channels

Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels

Genetic T-type calcium channelopathies

Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance

The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels