Rationale for the Combination of Dendritic Cell-Based Vaccination Approaches With Chemotherapy Agents
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
PubMed
28215530
DOI
10.1016/bs.ircmb.2016.09.003
PII: S1937-6448(16)30098-3
Knihovny.cz E-zdroje
- Klíčová slova
- Chemotherapy, Damage-associated molecular patterns, Dendritic cell, Immunogenic cell death, Immunotherapy,
- MeSH
- antitumorózní látky terapeutické užití MeSH
- dendritické buňky imunologie MeSH
- imunoterapie MeSH
- klinické zkoušky jako téma MeSH
- lidé MeSH
- protinádorové vakcíny imunologie MeSH
- vakcinace * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- antitumorózní látky MeSH
- protinádorové vakcíny MeSH
Owing to their central role in the initiation and regulation of antitumor immunity, dendritic cells (DCs) have been widely tested for use in cancer immunotherapy. Despite several encouraging clinical applications, existing DC-based immunotherapy efforts have yielded inconsistent results. Recent work has identified strategies that may allow for more potent DC-based vaccines, such as the combination with antitumor agents that have the potential to synergistically enhance DC functions. Selected cytotoxic agents may stimulate DCs either by directly promoting their maturation or through the induction of immunogenic tumor cell death. Moreover, they may support DC-induced adaptive immune responses by disrupting tumor-induced immunosuppressive mechanisms via selective depletion or inhibition of regulatory subsets, such as myeloid-derived suppressor cells and/or regulatory T cells (Tregs). Here, we summarize our current knowledge on the capacity of anticancer chemotherapeutics to modulate DC phenotype and functions and the results of ongoing clinical trials evaluating the use of DC-based immunotherapy in combination with chemotherapy in cancer patients.
2nd Faculty of Medicine and University Hospital Motol Prague Czech Republic
Faculty of Medicine and Faculty Hospital in Hradec Kralove Charles University Prague Czech Republic
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