Relative biological effectiveness in a proton spread-out Bragg peak formed by pencil beam scanning mode
Language English Country Netherlands Media print-electronic
Document type Journal Article
PubMed
28321635
DOI
10.1007/s13246-017-0540-8
PII: 10.1007/s13246-017-0540-8
Knihovny.cz E-resources
- Keywords
- Clonogennic assay, Micronuclei assay, Monte Carlo simulations, Proton therapy, Relative biological effectiveness, Scanning beam,
- MeSH
- Humans MeSH
- Linear Energy Transfer MeSH
- Micronucleus Tests MeSH
- Infant, Newborn MeSH
- Computer Simulation MeSH
- Protons * MeSH
- Radiometry MeSH
- Relative Biological Effectiveness * MeSH
- Cell Survival radiation effects MeSH
- Dose-Response Relationship, Radiation MeSH
- Check Tag
- Humans MeSH
- Infant, Newborn MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Protons * MeSH
In recent years, there is an increased interest in using scanning modes in proton therapy, due to the more conformal dose distributions, thanks to the spot-weighted dose delivery. The dose rate in each spot is however much higher than the dose rate when using passive irradiation modes, which could affect the cell response. The purpose of this work was to investigate how the relative biological effectiveness changes along the spread-out Bragg peak created by protons delivered by the pencil beam scanning mode. Cell survival and micronuclei formation were investigated in four positions along the spread-out Bragg peak for various doses. Monte Carlo simulations were used to estimate the dose-averaged linear energy transfer values in the irradiation positions. The cell survival was found to decrease the deeper the sample was placed in the spread-out Bragg peak, which corresponds to the higher linear energy transfer values found using Monte Carlo simulations. The micronuclei frequencies indicate more complex cell injuries at that distal position compared to the proximal part of the spread-out Bragg peak. The relative biological effectiveness determined in this study varies significantly and systematically from 1.1, which is recommended value by the International Commission on Radiation Units, in all the studied positions. In the distal position of spread-out Bragg peak the relative biological effectiveness values were found to be 2.05 ± 0.44, 1.85 ± 0.42, 1.53 ± 0.38 for survival levels 90, 50 and 10%, respectively.
Atominstitut Technische Universität Wien Stadionallee 2 1020 Vienna Austria
EBG MedAustron Marie Curie Straße 5 2700 Wiener Neustadt Vienna Austria
Nuclear Physics Institute of the Czech Academy of Sciences Řež 130 25068 Řež Czech Republic
Proton Therapy Center Czech Budínova 2437 1a 18000 Prague Czech Republic
References provided by Crossref.org
In Vitro Comparison of Passive and Active Clinical Proton Beams
