Warthin-like papillary renal cell carcinoma: Clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 11 cases
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28325361
DOI
10.1016/j.anndiagpath.2017.01.005
PII: S1092-9134(17)30020-5
Knihovny.cz E-zdroje
- Klíčová slova
- Chromosomal aberration pattern, Immunohistochemistry, Kidney, Lymphoid stroma, Oncocytic papillary renal cell carcinoma, Warthin's tumor, Warthin-like,
- MeSH
- genetická predispozice k nemoci MeSH
- genetické testování metody MeSH
- hybridizace in situ fluorescenční metody MeSH
- imunohistochemie metody MeSH
- karcinom z renálních buněk diagnóza genetika patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- nádorové biomarkery analýza MeSH
- nádory ledvin diagnóza genetika patologie MeSH
- oxyfilní adenom genetika patologie MeSH
- papilární karcinom genetika patologie MeSH
- senioři MeSH
- variabilita počtu kopií segmentů DNA genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- nádorové biomarkery MeSH
Oncocytic papillary renal cell carcinoma (PRCC) is a distinct subtype of PRCC, listed as a possible new variant of PRCC in the 2016 WHO classification. It is composed of papillae aligned by large single-layered eosinophilic cells showing linearly arranged oncocytoma-like nuclei. We analyzed clinicopathologic, morphologic, immunohistochemical and molecular-genetic characteristics of 11 oncocytic PRCCs with prominent tumor lymphocytic infiltrate, morphologically resembling Warthin's tumor. The patients were predominantly males (8/11, 73%), with an average age of 59years (range 14-76), and a mean tumor size of 7cm (range 1-22cm). Tumors had the features of oncocytic PRCCs with focal pseudostratification in 8/11 cases and showed dense stromal inflammatory infiltration in all cases. Papillary growth pattern was predominant, comprising more than 60% of tumor volume. Tubular and solid components were present in 5 and 3 cases, respectively. Uniform immunohistochemical positivity was found for AMACR, PAX-8, MIA, vimentin, and OSCAR. Tumors were mostly negative for carboanhydrase 9, CD117, CK20, and TTF-1. Immunohistochemical stains for DNA mismatch repair proteins MLH1 and PMS2 were retained in all cases, while MSH2 and MSH6 were negative in 1 case. Tumor infiltrating lymphocytes (TILs) consisted of both B and T cells. Chromosomal copy number variation analysis showed great variability in 5 cases, ranging from a loss of one single chromosome to complex genome rearrangements. Only one case showed gains of chromosomes 7 and 17, among other aberrations. In 4 cases no numerical imbalance was found. Follow up data was available for 9 patients (median 47.6months, range 1-132). In 6 patients no lethal progression was noted, while 3 died of disease. In conclusion, Warthin-like PRCC is morphologically very close to oncocytic PRCC, from which it differs by the presence of dense lymphoid stroma. Chromosomal numerical aberration pattern of these tumors is variable; only one case showed gains of chromosomes 7 and 17. Warthin-like PRCC is a potentially aggressive tumor since a lethal outcome was recorded in 3/9 cases.
Biopticka Laboratory Pilsen Czech Republic
Department of Pathology Bellvitge University Hospital Barcelona Spain
Department of Pathology Centro Medico Mexico City Mexico
Department of Pathology Instituto Nacional de Cancerologia Mexico City Mexico
Department of Pathology Masaryk's Oncologic Institute University Hospital Brno Czech Republic
Department of Pathology University of British Columbia Royal Columbian Hospital Vancouver BC Canada
Department of Pathology University of Sarajevo Clinical Center Sarajevo Bosnia and Herzegovina
Department of Radiation Oncology Oncology Institute Kosice Slovakia
Department Pathology Regional Hospital Jindrichuv Hradec Czech Republic
Department Pathology Regional Hospital Most Czech Republic
Ljudevit Jurak Pathology Department Clinical Hospital Center Sestre milosrdnice Zagreb Croatia
Citace poskytuje Crossref.org
Molecular Genetics of Renal Cell Tumors: A Practical Diagnostic Approach