Early detection of sporadic pancreatic cancer: time for change
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, přehledy
- MeSH
- časná detekce nádoru * MeSH
- časové faktory MeSH
- duktální karcinom pankreatu diagnóza mortalita terapie MeSH
- hodnocení rizik MeSH
- lidé MeSH
- nádory slinivky břišní diagnóza mortalita terapie MeSH
- prediktivní hodnota testů MeSH
- prognóza MeSH
- rizikové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Sporadic pancreatic cancer amounts to ∼90% of all pancreatic cancers. It is a gloomy depressive disease and the most recalcitrant malignancy, with a very low 5-year survival (3-6%). At present, diagnostic methods are commonly applied, as used half a century ago, after the appearance of local and systemic symptoms (abdominal and back pain, cholestasis, painless jaundice, fatigue, anorexia, weight loss, anemia, peripheral phlebitis, and cachexia). Unfortunately, these symptoms are harbingers of an advanced disease. The subsequent imaging methods may offer additional information on the location, size, and morphology of the lesion, but they do not influence the prognosis. Radical surgery may be offered to 15-20% of patients. The relapses after surgery are frequent and chemotherapy may be palliative. Preventive programs represent the only possibility of improvement. We propose the first multistep and multidisciplinary preventive program for early detection of sporadic pancreatic cancer for the differential identification of average-risk patients who probably have the disease from those who do not.
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