Possitive correlation between adipocyte fatty acid-binding protein and epicardial fat in patients with a family history of cardiovascular disesase
Language English Country Czech Republic Media print-electronic
Document type Journal Article
PubMed
28539672
DOI
10.5507/bp.2017.018
Knihovny.cz E-resources
- Keywords
- Adipocyte fatty acid bindig protein, echocardiography, epicardial fat, risk of cardiovascular disease,
- MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Cardiovascular Diseases blood physiopathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Obesity blood physiopathology MeSH
- Pericardium physiopathology MeSH
- Pilot Projects MeSH
- Fatty Acid-Binding Proteins blood MeSH
- Risk Factors MeSH
- Aged MeSH
- Adipose Tissue physiopathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Biomarkers MeSH
- Fatty Acid-Binding Proteins MeSH
BACKGROUND: Adipocyte fatty acid-binding protein (A-FABP) is a promising link between metabolic syndrome and atherosclerosis. Epicardial fat (EPI) is an independent risk factor for cardiovascular disease (CVD). OBJECTIVE: The aim of this pilot study was to evaluate the correlation between EPI and A-FABP in asymptomatic patients with a family history of CVD. METHODS: 59 subjects (39 males) (median = 54 years old) were enrolled in the study and their EPI thickness and A-FABP levels were assessed. RESULTS: EPI was found in 46 patients (77.9%). There were positive correlations between EPI and A-FABP (r=0.336; P=0.010), age (r=0.526; P<0.001), fibrinogen (r=0.304; P=0.023) and systolic blood pressure (r=0.279; P=0.034). A positive correlation was found between EPI and A-FABP in a subgroup of overweight and obese patients (0.389; P=0.041, 0.407; P=0.004) and in the subgroup of patients with excluded CVD (r=0.368; P=0.006). CONCLUSIONS: We found a positive correlation between EPI and A-FABP in a group of patients with a family history of CVD and in subgroups of overweight and obese patients.
Department of Esthetic Surgery University Hospital Olomouc Czech Republic
Department of Nuclear Medicine University Hospital Olomouc Czech Republic
Faculty of Medicine Saba University School of Medicine Saba Dutch Caribbean
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