Possitive correlation between adipocyte fatty acid-binding protein and epicardial fat in patients with a family history of cardiovascular disesase
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28539672
DOI
10.5507/bp.2017.018
Knihovny.cz E-zdroje
- Klíčová slova
- Adipocyte fatty acid bindig protein, echocardiography, epicardial fat, risk of cardiovascular disease,
- MeSH
- biologické markery krev MeSH
- dospělí MeSH
- kardiovaskulární nemoci krev patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- obezita krev patofyziologie MeSH
- perikard patofyziologie MeSH
- pilotní projekty MeSH
- proteiny vázající mastné kyseliny krev MeSH
- rizikové faktory MeSH
- senioři MeSH
- tuková tkáň patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- biologické markery MeSH
- proteiny vázající mastné kyseliny MeSH
BACKGROUND: Adipocyte fatty acid-binding protein (A-FABP) is a promising link between metabolic syndrome and atherosclerosis. Epicardial fat (EPI) is an independent risk factor for cardiovascular disease (CVD). OBJECTIVE: The aim of this pilot study was to evaluate the correlation between EPI and A-FABP in asymptomatic patients with a family history of CVD. METHODS: 59 subjects (39 males) (median = 54 years old) were enrolled in the study and their EPI thickness and A-FABP levels were assessed. RESULTS: EPI was found in 46 patients (77.9%). There were positive correlations between EPI and A-FABP (r=0.336; P=0.010), age (r=0.526; P<0.001), fibrinogen (r=0.304; P=0.023) and systolic blood pressure (r=0.279; P=0.034). A positive correlation was found between EPI and A-FABP in a subgroup of overweight and obese patients (0.389; P=0.041, 0.407; P=0.004) and in the subgroup of patients with excluded CVD (r=0.368; P=0.006). CONCLUSIONS: We found a positive correlation between EPI and A-FABP in a group of patients with a family history of CVD and in subgroups of overweight and obese patients.
Department of Esthetic Surgery University Hospital Olomouc Czech Republic
Department of Nuclear Medicine University Hospital Olomouc Czech Republic
Faculty of Medicine Saba University School of Medicine Saba Dutch Caribbean
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