Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review
Language English Country Sweden Media print
Document type Journal Article, Review
PubMed
28759178
PII: NEL380317R01
Knihovny.cz E-resources
- MeSH
- Anodontia genetics MeSH
- Axin Protein genetics MeSH
- Genetic Predisposition to Disease MeSH
- Genotype MeSH
- Humans MeSH
- Mutation MeSH
- Neoplasms genetics MeSH
- Polymorphism, Genetic MeSH
- Risk Factors MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Axin Protein MeSH
- AXIN2 protein, human MeSH Browser
AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer. These findings support the hypothesis that missing teeth may be a significant marker for predisposition for cancer.