Biotransformation of flubendazole and fenbendazole and their effects in the ribwort plantain (Plantago lanceolata)
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28934712
DOI
10.1016/j.ecoenv.2017.09.020
PII: S0147-6513(17)30596-1
Knihovny.cz E-zdroje
- Klíčová slova
- Drug metabolism, Drug uptake, Fenbendazole, Flubendazole, Phytotoxicity, UHPLC-MS/MS,
- MeSH
- anthelmintika metabolismus toxicita MeSH
- biotransformace MeSH
- fenbendazol metabolismus toxicita MeSH
- mebendazol analogy a deriváty metabolismus toxicita MeSH
- metabolické sítě a dráhy účinky léků MeSH
- oxidační stres účinky léků MeSH
- Plantago účinky léků enzymologie růst a vývoj MeSH
- veterinární léky metabolismus toxicita MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- anthelmintika MeSH
- fenbendazol MeSH
- flubendazole MeSH Prohlížeč
- mebendazol MeSH
- veterinární léky MeSH
Although veterinary anthelmintics represent an important source of environmental pollution, the fate of anthelmintics and their effects in plants has not yet been studied sufficiently. The aim of our work was to identify metabolic pathways of the two benzimidazole anthelmintics fenbendazole (FBZ) and flubendazole (FLU) in the ribwort plantain (Plantago lanceolata L.). Plants cultivated as in vitro regenerants were used for this purpose. The effects of anthelmintics and their biotransformation products on plant oxidative stress parameters were also studied. The obtained results showed that the enzymatic system of the ribwort plantain was able to uptake FLU and FBZ, translocate them in leaves and transform them into several metabolites, particularly glycosides. Overall, 12 FLU and 22 FBZ metabolites were identified in the root, leaf base and leaf top of the plant. Concerning the effects of FLU and FBZ, both anthelmintics in the ribwort plantain cells caused significant increase of proline concentration (up to twice), a well-known stress marker, and significant decrease of superoxide dismutase activity (by 50%). In addition, the activities of four other antioxidant enzymes were significantly changed after either FLU or FBZ exposition. This could indicate a certain risk of oxidative damage in plants influenced by anthelmintics, particularly when they are under other stress conditions.
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