In recent years, there has been increasing concern over the environmental risks of the so called "Emerging pollutants (EPs)" that are defined as synthetic or naturally occurring chemicals that are not commonly monitored in the environment but which have the potential to enter the environment and cause adverse ecological and (or) human health effects [...].

Institute of Experimental Botany Czech Academy of Sciences Rozvojová 263 CZ 16502 Prague Czech Republic

Zobrazit více v PubMed

Bisognin R.P., Wolff D.B., Carissimi E., Prestes O.D., Zanella R. Occurrence and fate of pharmaceuticals in effluent and sludge from a wastewater treatment plant in Brazil. Environ. Technol. 2021;42:2292–2303. doi: 10.1080/09593330.2019.1701561. PubMed DOI

Bartikova H., Skalova L., Stuchlikova L., Vokral I., Vanek T., Podlipna R. Xenobiotic-metabolizing enzymes in plants and their role in uptake and biotransformation of veterinary drugs in the environment. Drug Metab. Rev. 2015;47:374–387. doi: 10.3109/03602532.2015.1076437. PubMed DOI

Horvat A.J.M., Babić S., Pavlović D.M., Ašperger D., Pelko S., Kaštelan-Macan M., Petrović M., Mance A.D. Analysis, occurrence and fate of anthelmintics and their transformation products in the environment. TrAC Trends Anal. Chem. 2012;31:61–84. doi: 10.1016/j.trac.2011.06.023. DOI

Boxall A.B.A., Kolpin D.W., Halling-Sorensen B., Tolls J. Are veterinary medicines causing environmental risks? Environ. Sci. Technol. 2003;37:286A–294A. doi: 10.1021/es032519b. PubMed DOI

Dogra N., Kumar A., Mukhopadhyay T. Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways. Sci. Rep. 2018;8:11926. doi: 10.1038/s41598-018-30158-6. PubMed DOI PMC

Podlipna R., Skalova L., Seidlova H., Szotakova B., Kubicek V., Stuchlikova L., Jirasko R., Vanek T., Vokral I. Biotransformation of benzimidazole anthelmintics in reed (Phragmites australis) as a potential tool for their detoxification in environment. Bioresour. Technol. 2013;144:216–224. doi: 10.1016/j.biortech.2013.06.105. PubMed DOI

Stuchlikova L., Jirasko R., Skalova L., Pavlik F., Szotakova B., Holcapek M., Vanek T., Podlipna R. Metabolic pathways of benzimidazole anthelmintics in harebell (Campanula rotundifolia) Chemosphere. 2016;157:10–17. doi: 10.1016/j.chemosphere.2016.05.015. PubMed DOI

Raisova L.S., Podlipna R., Szotakova B., Syslova E., Skalova L. Evaluation of drug uptake and deactivation in plant: Fate of albendazole in ribwort plantain (Plantago laceolata) cells and regenerants. Ecotoxicol. Environ. Saf. 2017;141:37–42. doi: 10.1016/j.ecoenv.2017.03.014. PubMed DOI

Navratilova M., Stuchlikova L.R., Matouskova P., Ambroz M., Lamka J., Vokral I., Szotakova B., Skalova L. Proof of the environmental circulation of veterinary drug albendazole in real farm conditions. Environ. Pollut. 2021;286:117590. doi: 10.1016/j.envpol.2021.117590. PubMed DOI

Raza A., Qamar A.G., Hayat K., Ashraf S., Williams A.R. Anthelmintic resistance and novel control options in equine gastrointestinal nematodes. Parasitology. 2019;146:425–437. doi: 10.1017/S0031182018001786. PubMed DOI

Weiss K., Schussler W., Porzelt M. Sulfamethazine and flubendazole in seepage water after the sprinkling of manured areas. Chemosphere. 2008;72:1292–1297. doi: 10.1016/j.chemosphere.2008.04.053. PubMed DOI

Wagil M., Bialk-Bielinska A., Puckowski A., Wychodnik K., Maszkowska J., Mulkiewicz E., Kumirska J., Stepnowski P., Stolte S. Toxicity of anthelmintic drugs (fenbendazole and flubendazole) to aquatic organisms. Environ. Sci. Pollut. Res. 2015;22:2566–2573. doi: 10.1007/s11356-014-3497-0. PubMed DOI PMC

Zrncic M., Gros M., Babic S., Kastelan-Macan M., Barcelo D., Petrovic M. Analysis of anthelmintics in surface water by ultra high performance liquid chromatography coupled to quadrupole linear ion trap tandem mass spectrometry. Chemosphere. 2014;99:224–232. doi: 10.1016/j.chemosphere.2013.10.091. PubMed DOI

Sim W.J., Kim H.Y., Choi S.D., Kwon J.H., Oh J.E. Evaluation of pharmaceuticals and personal care products with emphasis on anthelmintics in human sanitary waste, sewage, hospital wastewater, livestock wastewater and receiving water. J. Hazard. Mater. 2013;248:219–227. doi: 10.1016/j.jhazmat.2013.01.007. PubMed DOI

Stuchlikova L.R., Skalova L., Szotakova B., Syslova E., Vokral I., Vanek T., Podlipna R. Biotransformation of flubendazole and fenbendazole and their effects in the ribwort plantain (Plantago lanceolata) Ecotoxicol. Environ. Saf. 2018;147:681–687. doi: 10.1016/j.ecoenv.2017.09.020. PubMed DOI

Syslova E., Landa P., Navratilova M., Stuchlikova L.R., Matouskova P., Skalova L., Szotakova B., Vanek T.S., Podlipna R. Ivermectin biotransformation and impact on transcriptome in Arabidopsis thaliana. Chemosphere. 2019;234:528–535. doi: 10.1016/j.chemosphere.2019.06.102. PubMed DOI

Podlipna R., Navratilova M., Stuchlikova L.R., Motkova K., Langhansova L., Skalova L., Szotakova B. Soybean (Glycine max) Is Able to Absorb, Metabolize and Accumulate Fenbendazole in All Organs Including Beans. Int. J. Mol. Sci. 2021;22:6647. doi: 10.3390/ijms22136647. PubMed DOI PMC