Ultrasound characteristics of endometrial cancer as defined by International Endometrial Tumor Analysis (IETA) consensus nomenclature: prospective multicenter study
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu hodnotící studie, časopisecké články, multicentrická studie
PubMed
28944985
DOI
10.1002/uog.18909
Knihovny.cz E-zdroje
- Klíčová slova
- Doppler, diagnostic imaging, endometrial neoplasm, neoplasm staging, ultrasonography,
- MeSH
- dospělí MeSH
- konsensuální konference jako téma MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory endometria klasifikace diagnostické zobrazování patologie MeSH
- prospektivní studie MeSH
- průřezové studie MeSH
- reprodukovatelnost výsledků MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stupeň nádoru * MeSH
- terminologie jako téma MeSH
- ultrasonografie dopplerovská barevná normy MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- multicentrická studie MeSH
OBJECTIVE: To describe the sonographic features of endometrial cancer in relation to tumor stage, grade and histological type, using the International Endometrial Tumor Analysis (IETA) terminology. METHODS: This was a prospective multicenter study of 1714 women with biopsy-confirmed endometrial cancer undergoing standardized transvaginal grayscale and Doppler ultrasound examination according to the IETA study protocol, by experienced ultrasound examiners using high-end ultrasound equipment. Clinical and sonographic data were entered into a web-based database. We assessed how strongly sonographic characteristics, according to IETA, were associated with outcome at hysterectomy, i.e. tumor stage, grade and histological type, using univariable logistic regression and the c-statistic. RESULTS: In total, 1538 women were included in the final analysis. Median age was 65 (range, 27-98) years, median body mass index was 28.4 (range 16-67) kg/m2 , 1377 (89.5%) women were postmenopausal and 1296 (84.3%) reported abnormal vaginal bleeding. Grayscale and color Doppler features varied according to grade and stage of tumor. High-risk tumors, compared with low-risk tumors, were less likely to have regular endometrial-myometrial junction (difference of -23%; 95% CI, -27 to -18%), were larger (mean endometrial thickness; difference of +9%; 95% CI, +8 to +11%), and were more likely to have non-uniform echogenicity (difference of +7%; 95% CI, +1 to +13%), a multiple, multifocal vessel pattern (difference of +21%; 95% CI, +16 to +26%) and a moderate or high color score (difference of +22%; 95% CI, +18 to +27%). CONCLUSION: Grayscale and color Doppler sonographic features are associated with grade and stage of tumor, and differ between high- and low-risk endometrial cancer. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
Center of Obstetrics and Gynecology Vilnius University Hospital Santariskiu Clinic Vilnius Lithuania
Clinic of Obstetrics and Gynecology University of Milan Bicocca San Gerardo Hospital Monza Italy
Department of Development and Regeneration KU Leuven Leuven Belgium
Department of Gynecological Oncology Catholic University of the Sacred Heart Rome Italy
Department of Gynecological Oncology European Institute of Oncology Milan Italy
Department of Obstetrics and Gynecology Clinica Universidad de Navarra Pamplona Spain
Department of Obstetrics and Gynecology Clinical Sciences Institute L Sacco Milan Italy
Department of Obstetrics and Gynecology Karolinska University Hospital Huddinge Stockholm Sweden
Department of Obstetrics and Gynecology National Cancer Institute Milan Italy
Department of Obstetrics and Gynecology Skåne University Hospital Malmö Lund University Sweden
Department of Obstetrics and Gynecology University Hospital Leuven Leuven Belgium
Department of Obstetrics and Gynecology Ziekenhuis Oost Limburg Genk Belgium
Department of Obstetrics Gynecology and Reproduction Hospital Universitario Dexeus Barcelona Spain
Department of Pathology Karolinska University Hospital Stockholm Sweden
Nuffield Department of Primary Care Health Sciences University of Oxford Oxford UK
Citace poskytuje Crossref.org
