The origin of 7alpha-hydroxy-dehydroepiandrosterone and its physiological role: a history of discoveries
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, přehledy
PubMed
28948812
DOI
10.33549/physiolres.933717
PII: 933717
Knihovny.cz E-zdroje
- MeSH
- dehydroepiandrosteron izolace a purifikace fyziologie MeSH
- duševní poruchy metabolismus patofyziologie MeSH
- hydrokortison metabolismus MeSH
- lidé MeSH
- mozek metabolismus patofyziologie MeSH
- nemoci nervového systému metabolismus patofyziologie MeSH
- obezita metabolismus patofyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- dehydroepiandrosteron MeSH
- hydrokortison MeSH
Nearly 60 years has elapsed since the first isolation and identification of 7alpha-hydroxy-dehydroepiandrosterone, and in that time much information has been gained on its occurrence, metabolism, ontogeny, immunomodulatory activity, cell proliferation, cortisol control in local tissues and neuroactivity. Additional knowledge about this steroid may elucidate its role in obesity, neurodegenerative disturbances such as Alzheimer's disease, or psychiatric disorders such as schizophrenia or depression. This review aims to provide a comprehensive summary of the available literature on 7alpha-hydroxy-dehydroepiandrosterone.
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