The origin of 7alpha-hydroxy-dehydroepiandrosterone and its physiological role: a history of discoveries
Language English Country Czech Republic Media print
Document type Journal Article, Review
PubMed
28948812
DOI
10.33549/physiolres.933717
PII: 933717
Knihovny.cz E-resources
- MeSH
- Dehydroepiandrosterone isolation & purification physiology MeSH
- Mental Disorders metabolism physiopathology MeSH
- Hydrocortisone metabolism MeSH
- Humans MeSH
- Brain metabolism physiopathology MeSH
- Nervous System Diseases metabolism physiopathology MeSH
- Obesity metabolism physiopathology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Dehydroepiandrosterone MeSH
- Hydrocortisone MeSH
Nearly 60 years has elapsed since the first isolation and identification of 7alpha-hydroxy-dehydroepiandrosterone, and in that time much information has been gained on its occurrence, metabolism, ontogeny, immunomodulatory activity, cell proliferation, cortisol control in local tissues and neuroactivity. Additional knowledge about this steroid may elucidate its role in obesity, neurodegenerative disturbances such as Alzheimer's disease, or psychiatric disorders such as schizophrenia or depression. This review aims to provide a comprehensive summary of the available literature on 7alpha-hydroxy-dehydroepiandrosterone.
References provided by Crossref.org
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