Vitamin D had been for a long time investigated for its effects on bone metabolism. Recently has been observed that the incidence of some neurodevelopmental disorders (including autism) increases hand in hand with vitamin D deficiency. Indeed, vitamin D was reported to modulate the biosynthesis of neurotransmitters and neurotrophic factors; moreover, its receptor was found in the central nervous system. Vitamin D deficiency was therefore assessed as a risk factor for autism, however the biological mechanism has not yet been revealed. In our review we focused on potential connections among vitamin D, steroids and autism. Potential mechanisms of vitamin D action are also discussed.
- MeSH
- autistická porucha farmakoterapie etiologie metabolismus MeSH
- epigeneze genetická účinky léků fyziologie MeSH
- lidé MeSH
- mozek účinky léků metabolismus MeSH
- nedostatek vitaminu D komplikace farmakoterapie metabolismus MeSH
- neurotransmiterové látky metabolismus terapeutické užití MeSH
- vitamin D metabolismus terapeutické užití MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Nearly 60 years has elapsed since the first isolation and identification of 7alpha-hydroxy-dehydroepiandrosterone, and in that time much information has been gained on its occurrence, metabolism, ontogeny, immunomodulatory activity, cell proliferation, cortisol control in local tissues and neuroactivity. Additional knowledge about this steroid may elucidate its role in obesity, neurodegenerative disturbances such as Alzheimer's disease, or psychiatric disorders such as schizophrenia or depression. This review aims to provide a comprehensive summary of the available literature on 7alpha-hydroxy-dehydroepiandrosterone.
- MeSH
- dehydroepiandrosteron izolace a purifikace fyziologie MeSH
- duševní poruchy metabolismus patofyziologie MeSH
- hydrokortison metabolismus MeSH
- lidé MeSH
- mozek metabolismus patofyziologie MeSH
- nemoci nervového systému metabolismus patofyziologie MeSH
- obezita metabolismus patofyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
