Deregulation of selected microRNAs in sinonasal carcinoma: Value of miR-21 as prognostic biomarker in sinonasal squamous cell carcinoma
Language English Country United States Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
28960576
DOI
10.1002/hed.24930
Knihovny.cz E-resources
- Keywords
- biomarker, head and neck cancer, miR-21, microRNA, sinonasal carcinoma,
- MeSH
- Survival Analysis MeSH
- Analysis of Variance MeSH
- Immunohistochemistry MeSH
- Biopsy, Needle MeSH
- Kaplan-Meier Estimate MeSH
- Real-Time Polymerase Chain Reaction methods MeSH
- Middle Aged MeSH
- Humans MeSH
- MicroRNAs genetics MeSH
- Biomarkers, Tumor genetics MeSH
- Paranasal Sinus Neoplasms genetics mortality pathology surgery MeSH
- Statistics, Nonparametric MeSH
- Prognosis MeSH
- Gene Expression Regulation, Neoplastic * MeSH
- Reproducibility of Results MeSH
- Aged MeSH
- Carcinoma, Squamous Cell genetics mortality pathology surgery MeSH
- Gene Expression Profiling MeSH
- Case-Control Studies MeSH
- Up-Regulation MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- MicroRNAs MeSH
- MIRN21 microRNA, human MeSH Browser
- Biomarkers, Tumor MeSH
BACKGROUND: Tumors occurring in the sinonasal area are characterized by unfavorable outcome due to difficult diagnosis, treatment, and prognosis of the disease corresponding with the anatomic complexity of the area. METHODS: We used quantitative real-time polymerase chain reaction (PCR) to compare relative expression of miR-21, miR-141, and miR-200c in 70 formalin-fixed, paraffin-embedded samples of sinonasal carcinoma tissue (majority of squamous cell carcinoma [SCC] samples) with 17 control samples of sinonasal tissue. RESULTS: Our data showed significant upregulation of miR-21 in sinonasal cancer tissue. Expression levels of miR-141 and miR-200c were below detectable levels in both sinonasal cancer samples and healthy tissue. Kaplan-Meier analysis with log-rank survival showed that patients with SCC with high expression of miR-21 (highest quartile) had impaired survival close to reaching statistical significance (P = .0630). CONCLUSION: Our results suggest that miR-21 upregulation is involved in tumorigenesis of sinonasal carcinoma and that it is associated with poor prognosis. Thus, miR-21 could be used as a valuable prognostic biomarker.
References provided by Crossref.org
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