Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions
Language English Country Switzerland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
29059672
DOI
10.1159/000479828
PII: 000479828
Knihovny.cz E-resources
- Keywords
- BMP2, Case-control study, DLX3, Dental caries, Gene polymorphism,
- MeSH
- Alleles MeSH
- Dentition, Permanent MeSH
- Child MeSH
- DMF Index MeSH
- Genetic Predisposition to Disease MeSH
- Genotype MeSH
- Homeodomain Proteins genetics MeSH
- Polymorphism, Single Nucleotide * MeSH
- Bone Morphogenetic Protein 2 genetics MeSH
- Humans MeSH
- Adolescent MeSH
- Child, Preschool MeSH
- Severity of Illness Index MeSH
- Transcription Factors genetics MeSH
- Dental Caries genetics MeSH
- Tooth, Deciduous MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- BMP2 protein, human MeSH Browser
- Distal-less homeobox proteins MeSH Browser
- Homeodomain Proteins MeSH
- Bone Morphogenetic Protein 2 MeSH
- Transcription Factors MeSH
The aim of this study was to analyze the association between BMP2 (rs1884302) and DLX3 (rs2278163) gene polymorphisms and dental caries in primary and permanent dentitions. A total of 914 subjects were genotyped by the TaqMan methods: 176 caries-free children (with Decayed/Missing/Filled Teeth, DMFT = 0), 542 patients with dental caries in permanent dentition (DMFT ≥1), 83 caries-free children with primary teeth (with decayed/missing/filled teeth, dmft = 0), and 113 children with early childhood caries (ECC, dmft ≥1). There were no significant differences in allele/genotype frequencies between patients with caries in permanent dentition/ECC and caries-free children or between patients with very low (DMFT = 0-2), low (DMFT = 3-5), moderate (DMFT = 6-8), or high (DMFT ≥9) caries experience. Variability in BMP2 and DLX3 was not associated with caries in the Czech population.
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