Comparison of the Copenhagen Index versus ROMA for the preoperative assessment of women with ovarian tumors
Language English Country United States Media print-electronic
Document type Comparative Study, Journal Article
PubMed
29086914
DOI
10.1002/ijgo.12371
Knihovny.cz E-resources
- Keywords
- Cancer antigen 125, Copenhagen Index, Human epididymis protein 4, Ovarian tumor, Risk of Ovarian Malignancy Algorithm,
- MeSH
- Algorithms * MeSH
- CA-125 Antigen blood MeSH
- Diagnosis, Differential MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Biomarkers, Tumor blood MeSH
- Ovarian Neoplasms blood classification diagnosis pathology MeSH
- Retrospective Studies MeSH
- Risk MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- CA-125 Antigen MeSH
- Biomarkers, Tumor MeSH
OBJECTIVE: To compare the Copenhagen Index (CPH-I) and the Risk of Ovarian Malignancy Algorithm (ROMA) in the differential diagnosis of ovarian tumors. METHODS: In a retrospective study, data were reviewed from women with ovarian tumors who attended University Hospital Brno, Czech Republic, between July 2011 and June 2015. The women were classified into the benign tumor group or malignant tumor group (borderline and malignant tumors). Serum levels of CA125 and HE4 were extracted from medical records. The two tumor indices were calculated using relevant clinical data. RESULTS: Among 267 included women, 110 had benign tumors, 42 had borderline ovarian tumors, and 115 had malignant tumors. The two indices showed similar discriminatory performance with no significant differences (P>0.05). In the differentiation of benign tumors from all stages of borderline tumor and ovarian cancer, ROMA showed a sensitivity of 71% at a specificity of 88%, whereas CPH-I showed a sensitivity of 69% at a specificity of 85%. CONCLUSION: CPH-I is a potential tumor index that is independent of menopausal status. It might be applied as a simple alternative to ROMA in settings of basic medical care.
Department of Biochemistry University Hospital Brno Brno Czech Republic
Department of Gynecology and Obstetrics Faculty of Medicine Masaryk University Brno Czech Republic
Department of Pathological Physiology Faculty of Medicine Masaryk University Brno Czech Republic
References provided by Crossref.org
