Characterization of isolated tau-reactive antibodies from the IVIG product, plasma of patients with Alzheimer's disease and cognitively normal individuals
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
29153604
DOI
10.1016/j.jneuroim.2017.09.011
PII: S0165-5728(17)30149-2
Knihovny.cz E-zdroje
- Klíčová slova
- Alzheimer's disease, Brain homogenates, Plasma antibodies, Reactivity profile, Tau protein,
- MeSH
- Alzheimerova nemoc krev imunologie patologie terapie MeSH
- fosforylace MeSH
- imunoglobulin G krev klasifikace MeSH
- intravenózní imunoglobuliny krev imunologie metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mozek metabolismus MeSH
- proteiny tau imunologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- imunoglobulin G MeSH
- intravenózní imunoglobuliny MeSH
- proteiny tau MeSH
The presence of natural tau-reactive antibodies was reported in human blood. In this study, we isolated and characterized natural tau-reactive antibodies occurring in IVIG product Flebogamma, plasma of patients with Alzheimer's disease (AD) and older cognitively normal persons (controls). Using blotting immunoassays and ELISA, we showed reactivity of antibodies obtained from IVIG and controls against a recombinant fragment of tau (155-421aa) and aggregates present in brains of AD patients. In contrast, antibodies isolated from plasma of AD patients reacted mainly with the recombinant full-length tau form and tau monomeric forms in brain tissue.
Department of Biological and Biochemical Sciences University of Pardubice Pardubice Czech Republic
Citace poskytuje Crossref.org
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