Characterization of isolated tau-reactive antibodies from the IVIG product, plasma of patients with Alzheimer's disease and cognitively normal individuals
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
29153604
DOI
10.1016/j.jneuroim.2017.09.011
PII: S0165-5728(17)30149-2
Knihovny.cz E-resources
- Keywords
- Alzheimer's disease, Brain homogenates, Plasma antibodies, Reactivity profile, Tau protein,
- MeSH
- Alzheimer Disease blood immunology pathology therapy MeSH
- Phosphorylation MeSH
- Immunoglobulin G blood classification MeSH
- Immunoglobulins, Intravenous blood immunology metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Brain metabolism MeSH
- tau Proteins immunology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Immunoglobulin G MeSH
- Immunoglobulins, Intravenous MeSH
- tau Proteins MeSH
The presence of natural tau-reactive antibodies was reported in human blood. In this study, we isolated and characterized natural tau-reactive antibodies occurring in IVIG product Flebogamma, plasma of patients with Alzheimer's disease (AD) and older cognitively normal persons (controls). Using blotting immunoassays and ELISA, we showed reactivity of antibodies obtained from IVIG and controls against a recombinant fragment of tau (155-421aa) and aggregates present in brains of AD patients. In contrast, antibodies isolated from plasma of AD patients reacted mainly with the recombinant full-length tau form and tau monomeric forms in brain tissue.
Department of Biological and Biochemical Sciences University of Pardubice Pardubice Czech Republic
References provided by Crossref.org
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