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Late preterm prelabor rupture of fetal membranes: fetal inflammatory response and neonatal outcome

Musilova, Ivana
Author Musilova, Ivana Department of Clinical Immunology and Allergy, University Hospital in Hradec Kralove, Charles University, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic
Andrys, Ctirad
Author Andrys, Ctirad Department of Clinical Immunology and Allergy, University Hospital in Hradec Kralove, Charles University, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic
Drahosova, Marcela
Author Drahosova, Marcela Department of Clinical Immunology and Allergy, University Hospital in Hradec Kralove, Charles University, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic
Zednikova, Barbora
Author Zednikova, Barbora Department of Clinical Immunology and Allergy, University Hospital in Hradec Kralove, Charles University, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic
Hornychova, Helena
Author Hornychova, Helena Fingerland's Department of Pathology, University Hospital in Hradec Kralove, Charles University, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic
Pliskova, Lenka
Author Pliskova, Lenka Institute of Clinical Biochemistry and Diagnostics, University Hospital in Hradec Kralove, Charles University, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic
Zemlickova, Helena
Author Zemlickova, Helena Institute of Clinical Microbiology, University Hospital in Hradec Kralove, Charles University, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic
Jacobsson, Bo
Author Jacobsson, Bo Department of Obstetrics and Gynecology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
Kacerovsky, Marian
Author Kacerovsky, Marian Department of Obstetrics and Gynecology, University Hospital in Hradec Kralove, Charles University, Faculty of Medicine Hradec Kralove, Hradec Kralove, Czech Republic

Pediatric research. 2018 Mar ; 83 (3) : 630-637. [epub] 20171220

Pediatr Res
ISSN 1530-0447 | 0031-3998
Source

Language English Country United States Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid29186106

PubMed 29186106
DOI 10.1038/pr.2017.300
PII: pr2017300
Knihovny.cz E-resources

MeSH
Chlamydia trachomatis MeSH
Chorioamnionitis microbiology MeSH
Adult MeSH
Enzyme-Linked Immunosorbent Assay MeSH
Fetal Blood chemistry MeSH
Gestational Age MeSH
Interleukin-6 blood MeSH
Humans MeSH
Mycoplasma hominis MeSH
Infant, Newborn MeSH
Placenta pathology MeSH
Amniotic Fluid microbiology MeSH
Fetal Membranes, Premature Rupture microbiology MeSH
Prospective Studies MeSH
Pregnancy MeSH
Ureaplasma metabolism MeSH
Vasculitis microbiology MeSH
Pregnancy Outcome MeSH
Inflammation microbiology MeSH
Check Tag
Adult MeSH
Humans MeSH
Infant, Newborn MeSH
Pregnancy MeSH
Female MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Names of Substances
IL6 protein, human MeSH Browser
Interleukin-6 MeSH

BackgroundTo characterize the influence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI) on the intensity of the fetal inflammatory response and the association between the presence of the fetal inflammatory response syndrome (FIRS) and short-term neonatal morbidity in the preterm prelabor rupture of membranes (PPROM) between the gestational ages of 34 and 37 weeks.MethodsOne hundred and fifty-nine women were included in the study. The umbilical cord blood interleukin (IL)-6 concentrations were determined using enzyme-linked immunosorbent assay kits. FIRS was defined based on the umbilical cord blood IL-6 concentration and the presence of funisitis and/or chorionic plate vasculitis.ResultsWomen with both MIAC and IAI had the highest median umbilical cord blood IL-6 concentrations and highest rates of FIRS. Women with FIRS had the higher rates of early-onset sepsis and intraventricular hemorrhage grades I and II when FIRS was characterized based on the umbilical cord blood IL-6 concentrations and the histopathological findings.ConclusionThe presence of both MIAC and IAI was associated with a higher fetal inflammatory response and a higher rate of FIRS. Different aspects of short-term neonatal morbidity were related to FIRS when defined by umbilical cord blood IL-6 concentrations and the histopathology of the placenta.

Department of Clinical Immunology and Allergy University Hospital in Hradec Kralove Charles University Faculty of Medicine Hradec Kralove Hradec Kralove Czech Republic

Department of Obstetrics and Gynecology Sahlgrenska Academy Gothenburg University Gothenburg Sweden

Department of Obstetrics and Gynecology University Hospital in Hradec Kralove Charles University Faculty of Medicine Hradec Kralove Hradec Kralove Czech Republic

Fingerland's Department of Pathology University Hospital in Hradec Kralove Charles University Faculty of Medicine Hradec Kralove Hradec Kralove Czech Republic

Institute of Clinical Biochemistry and Diagnostics University Hospital in Hradec Kralove Charles University Faculty of Medicine Hradec Kralove Hradec Kralove Czech Republic

Institute of Clinical Microbiology University Hospital in Hradec Kralove Charles University Faculty of Medicine Hradec Kralove Hradec Kralove Czech Republic

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