Evidence for verbal memory enhancement with electrical brain stimulation in the lateral temporal cortex
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Video-Audio Media
PubMed
29324988
DOI
10.1093/brain/awx373
PII: 4793032
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Adult MeSH
- Epilepsy complications MeSH
- Deep Brain Stimulation methods MeSH
- Middle Aged MeSH
- Humans MeSH
- Brain Mapping MeSH
- Young Adult MeSH
- Memory Disorders etiology therapy MeSH
- Temporal Lobe physiology MeSH
- Verbal Learning physiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Video-Audio Media MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
Direct electrical stimulation of the human brain can elicit sensory and motor perceptions as well as recall of memories. Stimulating higher order association areas of the lateral temporal cortex in particular was reported to activate visual and auditory memory representations of past experiences (Penfield and Perot, 1963). We hypothesized that this effect could be used to modulate memory processing. Recent attempts at memory enhancement in the human brain have been focused on the hippocampus and other mesial temporal lobe structures, with a few reports of memory improvement in small studies of individual brain regions. Here, we investigated the effect of stimulation in four brain regions known to support declarative memory: hippocampus, parahippocampal neocortex, prefrontal cortex and temporal cortex. Intracranial electrode recordings with stimulation were used to assess verbal memory performance in a group of 22 patients (nine males). We show enhanced performance with electrical stimulation in the lateral temporal cortex (paired t-test, P = 0.0067), but not in the other brain regions tested. This selective enhancement was observed both on the group level, and for two of the four individual subjects stimulated in the temporal cortex. This study shows that electrical stimulation in specific brain areas can enhance verbal memory performance in humans.awx373media15704855796001.
Dartmouth Hitchcock Medical Center Department of Neurology Lebanon NH USA
Emory University Department of Neurosurgery Atlanta GA USA
Mayo Clinic Department of Neurology Rochester MN USA
Mayo Clinic Department of Neurosurgery Rochester MN USA
Mayo Clinic Department of Physiology and Biomedical Engineering Rochester MN USA
Thomas Jefferson University Hospital Department of Neurology Philadelphia PA USA
Thomas Jefferson University Hospital Department of Radiology Philadelphia PA USA
University of Pennsylvania Department of Psychology Philadelphia PA USA
University of Pennsylvania Hospital Department of Neurology Philadelphia PA USA
University of Pennsylvania Hospital Department of Radiology Philadelphia PA USA
UT Southwestern Medical Center Department of Neurosurgery Dallas TX USA
References provided by Crossref.org
Modulating limbic circuits in temporal lobe epilepsy: impacts on seizures, memory, mood and sleep
Hotspot of human verbal memory encoding in the left anterior prefrontal cortex
Human Verbal Memory Encoding Is Hierarchically Distributed in a Continuous Processing Stream