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Interleukin 6 and complement serum level study in Parkinson's disease

Veselý, Branislav
Author Veselý, Branislav Department of Neurology, Faculty Hospital, Constantine the Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic Central European Institute of Technology (CEITEC), Brain and Mind Research Programme, 625 00, Brno, Czech Republic
Dufek, Michal
Author Dufek, Michal Movement Disorders Center, First Department of Neurology, Masaryk University, St. Anne's University Hospital, Pekařská 664/53, 656 91, Brno, Czech Republic
Thon, Vojtech
Author Thon, Vojtech Department of Clinical Immunology and Allergy, Faculty of Medicine, Masaryk University, St. Anne's University Hospital, 656 91, Brno, Czech Republic
Brozman, Miroslav
Author Brozman, Miroslav Department of Neurology, Faculty Hospital, Constantine the Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic
Királová, Silvia
Author Királová, Silvia Department of Clinical Psychology, Faculty Hospital, Constantine the Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic
Halászová, Tatiana
Author Halászová, Tatiana Department of Clinical Psychology, Faculty Hospital, Constantine the Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic
Koriťáková, Eva
Author Koriťáková, Eva Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 123/3, 625 00, Brno, Czech Republic
Rektor, Ivan
Author Rektor, Ivan Movement Disorders Center, First Department of Neurology, Masaryk University, St. Anne's University Hospital, Pekařská 664/53, 656 91, Brno, Czech Republic. irektor@med.muni.cz Central European Institute of Technology (CEITEC), Brain and Mind Research Programme, 625 00, Brno, Czech Republic. irektor@med.muni.cz

Journal of neural transmission (Vienna, Austria. 2018 May ; 125 (5) : 875-881. [epub] 20180212

J Neural Transm (Vienna)
ISSN 1435-1463 | 0300-9564
Source

Language English Country Austria Media print-electronic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link https://www.medvik.cz/link/pmid29435648

PubMed 29435648
DOI 10.1007/s00702-018-1857-5
PII: 10.1007/s00702-018-1857-5
Knihovny.cz E-resources

Keywords
Complement, Interleukin 6, Parkinson’s disease,
MeSH
Biomarkers blood MeSH
Interleukin-6 blood MeSH
Complement C4 analysis MeSH
Complement C3 analysis MeSH
Middle Aged MeSH
Humans MeSH
Longitudinal Studies MeSH
Parkinson Disease blood immunology MeSH
Aged MeSH
Check Tag
Middle Aged MeSH
Humans MeSH
Male MeSH
Aged MeSH
Female MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH
Names of Substances
Biomarkers MeSH
IL6 protein, human MeSH Browser
Interleukin-6 MeSH
Complement C4 MeSH
Complement C3 MeSH

The objective of this study is to assess whether elevation of serum inflammatory markers levels may indicate the progression of clinical impairment in Parkinson's disease (PD) patients. In 47 PD patients, the serum levels of the C3 and C4 part of the complement and Interleukin-6 (IL-6) were measured. The results at baseline and after 2 years were correlated with scales measuring memory, depression, motor symptoms, and quality of life. Patients with higher levels of C3 and C4 at baseline had decreased quality of life, verbal ability, and memory. Patients with higher IL-6 at baseline showed worse depression scores at 2 years. Patients with persistently higher levels of C3 and C4 at 2 years had worse quality of life and memory ability. Uncorrected p values are reported due to the exploratory nature of the study. The results indicate an impact of inflammation on non-motor signs and quality of life in PD. The increase of levels of serum inflammatory biomarkers may indicate the progression of non-motor impairment in PD.

Central European Institute of Technology Brain and Mind Research Programme 625 00 Brno Czech Republic

Department of Clinical Immunology and Allergy Faculty of Medicine Masaryk University St Anne's University Hospital 656 91 Brno Czech Republic

Department of Clinical Psychology Faculty Hospital Constantine the Philosopher University Špitálska 6 94901 Nitra Slovak Republic

Department of Neurology Faculty Hospital Constantine the Philosopher University Špitálska 6 94901 Nitra Slovak Republic

Institute of Biostatistics and Analyses Faculty of Medicine Masaryk University Kamenice 123 3 625 00 Brno Czech Republic

Movement Disorders Center 1st Department of Neurology Masaryk University St Anne's University Hospital Pekařská 664 53 656 91 Brno Czech Republic

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