Pseudohyperkalemia - Potassium released from cells due to clotting and centrifugation - a case report
Jazyk angličtina Země Chorvatsko Médium print-electronic
Typ dokumentu kazuistiky, časopisecké články
PubMed
29472808
PubMed Central
PMC5806620
DOI
10.11613/bm.2018.011002
PII: bm-28-1-011002
Knihovny.cz E-zdroje
- Klíčová slova
- case report, electrolytes, hyperkalemia, pseudohyperkalemia,
- MeSH
- biochemická analýza krve metody MeSH
- centrifugace MeSH
- diferenciální diagnóza MeSH
- draslík krev MeSH
- hemokoagulace MeSH
- hyperkalemie diagnóza MeSH
- Janus kinasa 2 genetika MeSH
- leukocyty cytologie metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- myeloproliferativní poruchy genetika patologie MeSH
- trombocyty cytologie metabolismus MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- draslík MeSH
- Janus kinasa 2 MeSH
Hyperkalemia is a potentially lethal condition. Pseudohyperkalemia should be always excluded before implementing treatment to prevent inappropriate cause of hypokalemia - equally a potentially lethal condition. Here we present a case report of a 62 year female with chronic myeloproliferative disorder, i.e. essential thrombocythemia. The laboratory test results for potassium concentration were 6.3 mmol/L, for platelet count 1305 x109/L and for leukocyte count 39.8 x109/L. This was due to a temporary drug withdrawal after a surgical intervention for gastric bleeding. Potassium concentration in lithium heparin plasma collected in a vacuum tube without gel separator and in whole blood syringe were 4.6 mmol/L and 3.4 mmol/L, respectively. It means that mechanical stress such as centrifugation can contribute to spurious hyperkalemia. Prior to reporting unexpected hyperkalemia result, pseudohyperkalemia should always be considered by the laboratory. Such potassium results require investigation in case it is pseudohyperkalemia, which may be due to thrombocytosis and leukocytosis. In cases where thrombocytosis or leukocytosis exists, an interpretative comment indicating these conditions inserted with the results of the potassium concentration can increase awareness for more accurate patient care decisions.
Department of Clinical biochemistry and pharmacology Tomas Bata hospital in Zlín Zlín Czech Republic
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