A Randomized, Multicenter, Double-Blind, Parallel Pilot Study Assessing the Effect of Mechanical Adhesiolysis vs Adhesiolysis with Corticosteroid and Hyaluronidase Administration into the Epidural Space During Epiduroscopy
Language English Country Great Britain, England Media print
Document type Journal Article, Multicenter Study, Randomized Controlled Trial
PubMed
29584916
DOI
10.1093/pm/pnx328
PII: 4953041
Knihovny.cz E-resources
- Keywords
- Adhesiolysis, Back Pain, Epiduroscopy, Failed Back Surgery Syndrome, Hyaluronidase,
- MeSH
- Tissue Adhesions drug therapy surgery MeSH
- Double-Blind Method MeSH
- Epidural Space surgery MeSH
- Failed Back Surgery Syndrome drug therapy surgery MeSH
- Adrenal Cortex Hormones therapeutic use MeSH
- Hyaluronoglucosaminidase therapeutic use MeSH
- Humans MeSH
- Methylprednisolone therapeutic use MeSH
- Neuroendoscopy methods MeSH
- Pilot Projects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Randomized Controlled Trial MeSH
- Names of Substances
- Adrenal Cortex Hormones MeSH
- Hyaluronoglucosaminidase MeSH
- Methylprednisolone MeSH
OBJECTIVE: Epiduroscopy is a proven method of diagnosis and treatment for chronic radicular pain after spinal surgery, which is known as failed back surgery syndrome (FBSS). The aim of the study was to compare the efficacy of drugs (the enzyme hyaluronidase and corticosteroid DEPO-Medrol) administrated into the epidural space during epiduroscopy, performed within the ventral and ventro-lateral epidural space with a focus on releasing foraminal adhesions. METHODS: Forty-eight patients with diagnosed FBBS were randomized into two groups before epiduroscopy. Group A received the standard treatment-mechanical lysis of fibrotic tissue in the epidural space. Group B received hyaluronidase and corticosteroid methylprednisolone acetate during the procedure. Subjects were followed for six and 12 months via scheduled double-blinded examinations by pain physicians. Leg and back pain intensity was assessed by an 11-point numerical rating scale, and patients' functional disability was assessed by the Oswestry Disability Index (ODI). RESULTS: Study subjects showed a significant decrease in ODI score in both groups (P < 0.05). Significantly lower pain scores for leg pain (P < 0.05) and back pain (P < 0.05) were also recorded after the six-month follow-up. However, the one-year follow-up showed a return to the baseline ODI values of most monitored pain scores in both groups (P > 0.05). Improvement was only noted on the NRS for back pain at one-year follow-up (P < 0.05). CONCLUSIONS: A significant improvement of leg and back pain was found in both groups after six months. ODI was significantly improved only in group B in both the six- and 12-month intervals. Back pain at one-year follow-up was only improved in group B.
Europainclinics Bardejov Slovak Republic
Europainclinics Nové Mesto Slovak Republic
Europainclinics Poliklinika Terasa Košice Slovak Republic
Europainclinics Prague Czech Republic
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