Paclitaxel-Loaded Polylactide/Polyethylene Glycol Fibers with Long-Term Antitumor Activity as a Potential Drug Carrier for Local Chemotherapy
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- Keywords
- PLA/PEG fibers, cytotoxicity, drug release, local chemotherapy, paclitaxel,
- MeSH
- Delayed-Action Preparations chemistry pharmacokinetics pharmacology MeSH
- Humans MeSH
- MCF-7 Cells MeSH
- Neoplasms drug therapy metabolism pathology MeSH
- Drug Carriers * chemistry pharmacokinetics pharmacology MeSH
- Paclitaxel * chemistry pharmacokinetics pharmacology MeSH
- Polyesters * chemistry pharmacokinetics pharmacology MeSH
- Polyethylene Glycols * chemistry pharmacokinetics pharmacology MeSH
- Antineoplastic Agents * chemistry pharmacokinetics pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Delayed-Action Preparations MeSH
- Drug Carriers * MeSH
- Paclitaxel * MeSH
- poly(lactide) MeSH Browser
- Polyesters * MeSH
- Polyethylene Glycols * MeSH
- Antineoplastic Agents * MeSH
Local application of anticancer agents prolongs the presence time and increases the concentration of drug in the target place and therefore may reduce serious side effects compared to drug systemic administration. The preparation of fibrous materials of polylactide (PLA) and polyethylene glycol (PEG) loaded with paclitaxel (PTX, 1 or 10 wt%) is presented. Scanning electron microscopy proves that PTX is homogeneously incorporated into the fibers. The addition of PEG of various molecular weights (6, 20, or 35 kDa) ensures the release of significantly higher amounts of hydrophobic PTX in a prolonged release time compared to the fibers containing PTX only. Present PLA-PEG fibrous carriers can serve as a drug depot for PTX since they exhibit significant toxicity for cancer cell lines in several-day experiment. They are promising for local recurrence therapy, where the initial release is efficient to kill tumor cells and continued release can prevent their subsequent proliferation.
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