Local application of anticancer agents prolongs the presence time and increases the concentration of drug in the target place and therefore may reduce serious side effects compared to drug systemic administration. The preparation of fibrous materials of polylactide (PLA) and polyethylene glycol (PEG) loaded with paclitaxel (PTX, 1 or 10 wt%) is presented. Scanning electron microscopy proves that PTX is homogeneously incorporated into the fibers. The addition of PEG of various molecular weights (6, 20, or 35 kDa) ensures the release of significantly higher amounts of hydrophobic PTX in a prolonged release time compared to the fibers containing PTX only. Present PLA-PEG fibrous carriers can serve as a drug depot for PTX since they exhibit significant toxicity for cancer cell lines in several-day experiment. They are promising for local recurrence therapy, where the initial release is efficient to kill tumor cells and continued release can prevent their subsequent proliferation.

Department of Analytical Chemistry Faculty of Science Charles University Hlavova 8 128 43 Prague 2 Czech Republic

Department of Oncology 2nd Medical Faculty Charles University and Motol University Hospital 5 uvalu 84 150 06 Prague 5 Czech Republic

Department of Pediatric Hematology and Oncology 2nd Medical Faculty Charles University and Motol University Hospital 5 uvalu 84 150 06 Prague 5 Czech Republic

Institute of Macromolecular Chemistry Academy of Sciences Heyrovsky Sq 2 162 06 Prague 6 Czech Republic

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