Sonolysis in risk reduction of symptomatic and silent brain infarctions during coronary stenting (SONOREDUCE): Randomized, controlled trial
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, randomizované kontrolované studie
PubMed
29859706
DOI
10.1016/j.ijcard.2018.05.101
PII: S0167-5273(18)30634-X
Knihovny.cz E-zdroje
- Klíčová slova
- Angioplasty, Coronary artery, Ischemic lesion, Sonolysis, Stenting, Stroke,
- MeSH
- asymptomatické nemoci MeSH
- balónková koronární angioplastika škodlivé účinky metody MeSH
- elektivní chirurgické výkony škodlivé účinky metody MeSH
- hodnocení rizik MeSH
- kognice MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie metody MeSH
- mozek diagnostické zobrazování MeSH
- mozkový infarkt * diagnóza etiologie patofyziologie psychologie MeSH
- neurologické vyšetření metody MeSH
- pooperační komplikace * diagnóza etiologie patofyziologie psychologie MeSH
- senioři MeSH
- trombolytická terapie * škodlivé účinky metody MeSH
- ultrazvuková terapie * škodlivé účinky metody MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
BACKGROUND: Silent brain infarcts can be detected on magnetic resonance imaging (MRI) in ~22% of patients after coronary angioplasty and stenting (CS). The effect of periprocedural sonolysis on the risk of new brain infarcts during CS was examined. METHODS: Patients undergoing elective CS were allocated randomly to a bilateral sonolysis group (70 patients, 58 men; mean age, 59.9 years) or a control group (74 patients, 45 men; mean age, 65.5 years). Neurologic examination, cognitive function tests, and brain MRI were performed prior to intervention and at 24 h after CS. Neurologic examination and cognitive function tests were repeated at 30 days after CS. RESULTS: No significant differences were observed in the number of patients with new infarcts (25.7 vs. 18.9%, P = 0.423), the number of lesions (1.3 ± 1.0 vs. 2.9 ± 5.3, P = 0.493), lesion volume (0.16 ± 0.34 vs. 0.28 ± 0.60 mL, P = 0.143), and the number of patients with new ischemic lesions in the insonated MCA territories (18.6vs. 17.6%, P = 0.958) between the sonolysis group and the control group. There were no cases of stroke, transient ischemic attack, myocardial infarction, or death in the two groups. Intracranial bleeding was reported only in 1 patient in the control group (0 vs. 1.4%, P = 0.888). Clock-drawing test scores at 30 days were significantly higher in the sonolysis group than in the control group (median 3.0 vs. 2.5, P = 0.031). CONCLUSIONS: Sonolysis does not reduce the risk of new brain infarcts after CS. The effect of sonolysis on number and volume of ischemic lesions and cognitive function should be assessed in further studies.
Centre for Research and Science Faculty of Health Sciences Palacký University Olomouc Czech Republic
Department of Neurology Faculty Hospital Nitra and Constantine Philosopher University Nitra Slovakia
Citace poskytuje Crossref.org
Sonolysis during carotid endarterectomy: randomised controlled trial
