Effect of Water-Soluble Echinochrome Analog on Arrhythmia Severity in Experimental Model of Acute Myocardial Ischemia
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
30006880
DOI
10.1007/s10517-018-4165-z
PII: 10.1007/s10517-018-4165-z
Knihovny.cz E-resources
- Keywords
- cats, echinochrome analog U-441, ischemia, predictors, ventricular arrhythmias,
- MeSH
- Anti-Arrhythmia Agents isolation & purification pharmacology MeSH
- Electrocardiography MeSH
- Myocardial Ischemia drug therapy physiopathology MeSH
- Sea Urchins chemistry MeSH
- Cats MeSH
- Coronary Occlusion surgery MeSH
- Disease Models, Animal MeSH
- Myocardium pathology MeSH
- Naphthoquinones isolation & purification pharmacology MeSH
- Treatment Failure MeSH
- Heart Conduction System drug effects physiopathology MeSH
- Solubility MeSH
- Arrhythmias, Cardiac drug therapy physiopathology MeSH
- Severity of Illness Index MeSH
- Water chemistry MeSH
- Animals MeSH
- Check Tag
- Cats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Arrhythmia Agents MeSH
- echinochrome A MeSH Browser
- Naphthoquinones MeSH
- Water MeSH
The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. Coronary occlusion increased activation time and decreased repolarization time in the ischemic zone; in addition, it increased both global and borderline (local) dispersions of repolarization. The linear regression model showed that only activation time values measured at the initial state and at termination of occlusion were associated with total arrhythmia score during ischemia (regression coefficient β=0.338, 95%CI=0.074-0.602, p=0.015 and β=0.720, 95%CI=0.323-1.117, p=0.001, respectively). The study revealed no association between administration of echinochrome analog U-441 and arrhythmia severity.
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