The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. Coronary occlusion increased activation time and decreased repolarization time in the ischemic zone; in addition, it increased both global and borderline (local) dispersions of repolarization. The linear regression model showed that only activation time values measured at the initial state and at termination of occlusion were associated with total arrhythmia score during ischemia (regression coefficient β=0.338, 95%CI=0.074-0.602, p=0.015 and β=0.720, 95%CI=0.323-1.117, p=0.001, respectively). The study revealed no association between administration of echinochrome analog U-441 and arrhythmia severity.

Department of Biomedical Technology Faculty of Biomedical Engineering Czech Technical University Prague Czech Republic

Department of Physiology Medical Institute of Pitirim Sorokin Syktyvkar State University Syktyvkar Russia

Department of Therapy Medical Institute of Pitirim Sorokin Syktyvkar State University Syktyvkar Russia

Institute of Physiology Komi Science Center Ural Division of Russian Academy of Sciences Syktyvkar Russia

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