Predictors of bone fractures in a single-centre cohort of hemodialysis patients: a 2-year follow-up study
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
Grantová podpora
00064173
MH CZ - DRO
PubMed
30117013
DOI
10.1007/s11255-018-1958-y
PII: 10.1007/s11255-018-1958-y
Knihovny.cz E-zdroje
- Klíčová slova
- Bone mineral density, FRAX, Fracture, Hemodialysis, Hip structure analysis, Trabecular bone score,
- MeSH
- acyltransferasy krev MeSH
- chronické selhání ledvin krev terapie MeSH
- fraktury kostí krev epidemiologie MeSH
- hemodiafiltrace MeSH
- index tělesné hmotnosti * MeSH
- kostní denzita MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- parathormon krev MeSH
- proteiny z Escherichia coli krev MeSH
- rizikové faktory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vitamin D analogy a deriváty krev MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 25-hydroxyvitamin D MeSH Prohlížeč
- acyltransferasy MeSH
- PagP protein, E coli MeSH Prohlížeč
- parathormon MeSH
- proteiny z Escherichia coli MeSH
- vitamin D MeSH
PURPOSE: Bone involvement represents one of the complications of end-stage chronic kidney disease, with fractures being its major risk. The aim of our study was to assess the frequency and predictors of low-trauma fractures in a cohort of maintenance hemodialysis patients followed-up on for 2 years. METHODS: 59 patients (67.6 ± 13.1 years, 43 males) treated with hemodiafiltration underwent initially laboratory (markers of calcium-phosphate metabolism and bone turnover markers) and densitometry examination with TBS assessment (Lunar Prodigy, TBS software 2.1.2). During 24-month follow-up, the frequency of low-trauma fractures was assessed and possible predictors of increased fracture risk were identified using product-moment correlation matrices. RESULTS: Altogether 7 (11.9%) low-trauma fractures were observed. In the whole group, age (P = 0.047), T-score in proximal femur (P = 0.04), low vitamin D, low BMI (P = 0.03 for both), and higher FRAX for major osteoporotic fracture (P = 0.01) were connected with fractures, but in multi-variate analysis only BMI remained significantly negatively associated with fractures (P = 0.047). TBS and bone turnover markers failed to predict fractures. However, women with fractures had significantly lower serum phosphate (P = 0.03) and higher parathyroid hormone (P = 0.04). Parameters of hip structure analysis significantly correlated with FRAX, but not with fractures. CONCLUSIONS: In a group of hemodialysis patients from one centre, T-score in proximal femur, low vitamin D, low BMI, and high FRAX for major osteoporotic fracture were associated with low-trauma fractures, however, in multi-variate analysis only low BMI remained a significant predictor of fracture risk.
Bone Metabolism Unit Affidea Prague Czech Republic
Dialysis Centre Fresenius Medical Care Vinohrady Prague Czech Republic
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