Investigation of melanoma-associated antigen A4 cancer/testis antigen clinical relevance in esophageal squamous cell carcinoma
Jazyk angličtina Země Indie Médium print
Typ dokumentu časopisecké články
PubMed
30197348
DOI
10.4103/0973-1482.183180
PII: JCanResTher_2018_14_5_1059_183180
Knihovny.cz E-zdroje
- Klíčová slova
- Cancer-testis antigens, esophageal squamous cell carcinoma, immunohistochemistry, melanoma-associated antigen A4, tumor marker,
- MeSH
- antigeny nádorové genetika MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- lymfatické metastázy genetika patologie MeSH
- nádorové biomarkery genetika MeSH
- nádorové proteiny genetika MeSH
- nádory jícnu genetika patologie MeSH
- přežití bez známek nemoci MeSH
- prognóza * MeSH
- regulace genové exprese u nádorů genetika MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- skvamózní karcinom jícnu MeSH
- spinocelulární karcinom genetika patologie MeSH
- staging nádorů MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny nádorové MeSH
- MAGEA4 protein, human MeSH Prohlížeč
- nádorové biomarkery MeSH
- nádorové proteiny MeSH
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is considered as the seventh most common cancer worldwide, and the second prevalent malignancy in the north of Iran. A subfamily group of tumor-specific antigens, commonly specified as cancer/testis antigens (CTAs), are expressed restrictedly in testis, ovary, and placenta. Melanoma-associated antigen A4 (MAGEA4) as a CTA is overexpressed in a variety of cancers. Expressional analysis of MAGEA4 protein in ESCC may be useful to investigate its clinical relevance leading to effective improvements in ESCC diagnosis and treatment. MATERIALS AND METHODS: Fifty-six ESCC patients with no preoperative therapeutic circumstance such as radiotherapy or chemotherapy were analyzed to explore the protein expression level of MAGEA4 using immunohistochemistry assay. RESULTS: MAGEA4 overexpression was detected in 66% of ESCC samples showing strong nuclear and cytoplasmic staining compared to the normal epithelium. There were significant correlations between MAGEA4 protein expression and depth of tumor invasion (P = 0.019), and the number of involved lymph nodes (P = 0.045). CONCLUSION: Because of the significant correlation of MAGEA4 and indices of poor prognosis, the role of this CTA may be confirmed in ESCC aggressiveness and metastasis. Therefore, MAGEA4 may be a promising therapeutic candidate for suppressing ESCC aggressiveness.
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