Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články
- Klíčová slova
- Induced pluripotent stem cells, Neural stem cells, Neuronal differentiation, Spinal cord injury, Stroke,
- MeSH
- buněčná diferenciace * MeSH
- cévní mozková příhoda patologie terapie MeSH
- indukované pluripotentní kmenové buňky cytologie MeSH
- lidé MeSH
- modely neurologické * MeSH
- nervové kmenové buňky cytologie MeSH
- poranění míchy patologie terapie MeSH
- přeprogramování buněk MeSH
- transkripční faktory metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- transkripční faktory MeSH
Induced pluripotent stem (iPS) cells are derived from differentiated cells by different reprogramming techniques, by introducing specific transcription factors responsible for pluripotency. Induced pluripotent stem cells can serve as an excellent source for differentiated neural stem/progenitor cells (NSCs/NPs). Several methods and protocols are utilized to create a robust number of NSCs/NPs without jeopardizing the safety issues required for in vivo applications. A variety of disease-specific iPS cells have been used to study nervous system diseases. In this chapter, we will focus on some of the derivation and differentiation approaches and the application of iPS-NPs in the treatment of spinal cord injury and stroke.
2nd Faculty of Medicine Charles University Prague Czech Republic
Institute of Experimental Medicine ASCR Prague Czech Republic
Citace poskytuje Crossref.org
