Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs and used to treat and/or manage human ailments such as metabolic, cardiovascular, neurological disorders and cancer. Thus, the purpose of this review is to emphasize the importance of flavonoids for the treatment of autoimmune diseases and put into the limelight of the scientific community several health-promoting effects of flavonoids which could be beneficial for the development of novel drugs from natural products. Despite available reviews on flavonoids targeting various disease conditions, a comprehensive review of flavonoids for autoimmune diseases is still lacking. To the best of our knowledge, this is the first attempt to review the potential of flavonoids for autoimmune diseases. The structure-activity relationship of flavonoids in this review revealed that the rearrangement and introduction of other functional groups into the basic skeleton of flavonoids might lead to the development of new drugs which will be helpful in relieving the painful symptoms of various autoimmune diseases.

Department of Biology Science Faculty Selcuk University Campus 42250 Konya Turkey

Department of Biotechnology Alagappa University Science Campus Karaikudi 603 003 India

Department of Health Sciences Faculty of Science University of Mauritius Réduit Mauritius

Department of Natural Drugs Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences Brno Palackého tř 1946 1 612 42 Brno Czech Republic

Department of Pharmaceutical Sciences Faculty of Technology Kumaun University Bhimtal 263136 Nainital Uttarakhand India

Department of Pharmacy Abdul Wali Khan University Mardan 23200 Pakistan

ESTG Polytechnic Institute of Leiria Portugal; UCIBIO Faculty of Science and Technology University NOVA of Lisbon Portugal

Citace poskytuje Crossref.org

Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights