The role of flavonoids in autoimmune diseases: Therapeutic updates
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
30268770
DOI
10.1016/j.pharmthera.2018.09.009
PII: S0163-7258(18)30174-8
Knihovny.cz E-resources
- Keywords
- Immune system, Inflammation, Medicinal plants, Multiple sclerosis, Polyphenols, Rheumatoid arthritis,
- MeSH
- Anti-Inflammatory Agents chemistry pharmacokinetics therapeutic use toxicity MeSH
- Autoimmune Diseases drug therapy genetics MeSH
- Flavonoids chemistry pharmacokinetics therapeutic use toxicity MeSH
- Humans MeSH
- Gene Expression Regulation drug effects MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Anti-Inflammatory Agents MeSH
- Flavonoids MeSH
Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs and used to treat and/or manage human ailments such as metabolic, cardiovascular, neurological disorders and cancer. Thus, the purpose of this review is to emphasize the importance of flavonoids for the treatment of autoimmune diseases and put into the limelight of the scientific community several health-promoting effects of flavonoids which could be beneficial for the development of novel drugs from natural products. Despite available reviews on flavonoids targeting various disease conditions, a comprehensive review of flavonoids for autoimmune diseases is still lacking. To the best of our knowledge, this is the first attempt to review the potential of flavonoids for autoimmune diseases. The structure-activity relationship of flavonoids in this review revealed that the rearrangement and introduction of other functional groups into the basic skeleton of flavonoids might lead to the development of new drugs which will be helpful in relieving the painful symptoms of various autoimmune diseases.
Department of Biology Science Faculty Selcuk University Campus 42250 Konya Turkey
Department of Biotechnology Alagappa University Science Campus Karaikudi 603 003 India
Department of Health Sciences Faculty of Science University of Mauritius Réduit Mauritius
Department of Pharmacy Abdul Wali Khan University Mardan 23200 Pakistan
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