Sex- and age-related differences of metabolic parameters in impaired glucose metabolism and type 2 diabetes compared to normal glucose tolerance
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
30287229
DOI
10.1016/j.diabres.2018.09.019
PII: S0168-8227(18)30758-7
Knihovny.cz E-zdroje
- Klíčová slova
- Beta-cell function, Disposition index, Gender differences, Insulin resistance, Insulin secretion, Prediabetes,
- MeSH
- diabetes mellitus 2. typu diagnóza metabolismus MeSH
- glukosa metabolismus MeSH
- glukózový toleranční test metody MeSH
- inzulin metabolismus MeSH
- inzulinová rezistence MeSH
- lidé středního věku MeSH
- lidé MeSH
- porucha glukózové tolerance metabolismus MeSH
- sexuální faktory MeSH
- věkové faktory MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- glukosa MeSH
- inzulin MeSH
AIMS: This study analysed potential sex differences in glucose metabolism of European subjects with different degrees of glucose tolerance impairment. METHODS: Subjects with impaired glucose metabolism, IGM (n = 735), or type 2 diabetes, T2DM (n = 415), were compared to subjects with normal glucose tolerance, NGT (n = 422), with similar BMI. For both males (M) and females (F), 50 years threshold was used for estimation of menopausal/andropausal state. Subjects underwent 75-g OGTT for measurements of insulin sensitivity (OGIS), beta-cell function (insulinogenic index, IGIC), and overall metabolic condition, disposition index (DI). RESULTS: In IGM, OGIS did not change with age in both sexes, whereas marked reduction of IGIC was seen in F (p = 0.0003). In T2DM, again OGIS did not change with age, but M ≥ 50 yrs had reduced IGIC and DI (p < 0.002) compared to M < 50 yrs. CONCLUSIONS: IGM did not reveal relevant changes of insulin resistance with age, but early phase insulin release deteriorated, with higher change in women. T2DM men featured age-related deterioration of glucose metabolism. In women, sex advantage seen in NGT vanished in T2DM, since glucose metabolism was overall not different than in men, both young and elderly.
Institute of Endocrinology Národní 8 PRAGUE 1 CZ 116 94 Prague Czech Republic
Internal Medicine Regional Hospital Via Castello 6777 30122 Venice Italy
Metabolic Unit CNR Institute of Neuroscience Corso Stati Uniti 4 35127 Padova Italy
Citace poskytuje Crossref.org
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